F. Zhao

The dual resistance mechanism of CYP325G4 and CYP6AA9 in Culex pipiens pallens legs according to transcriptome and proteome analysis

This study identifies CYP325G4 and CYP6AA9 as key P450 enzymes involved in deltamethrin resistance in Culex pipiens legs through transcriptome and proteome analysis.

Androgen receptor activity inversely correlates with immune cell infiltration and immunotherapy response across multiple cancer lineages

The paper examines the relationship between androgen receptor activity and immune cell infiltration, showing that lower AR activity correlates with increased immune activity and better immunotherapy response across multiple cancers.

Flotillin-2 dampens T cell antigen-sensitivity and functionality

This study shows that Flotillin-2 reduces T cell sensitivity to weak antigen stimulation by regulating TCR clustering and signaling.

Extracellular electron transfer drives efficient H2-independent methylotrophic methanogenesis by Methanomassiliicoccus, a seventh order methanogen

This study shows Methanomassiliicoccus uses extracellular electron transfer for efficient methylotrophic methanogenesis, enhancing methane production in coculture with electrogenic bacteria.

Chemoproteomics reveals immunogenic and tumor-associated cell surface substrates of ectokinase CK2α

The paper uses chemoproteomics to identify immunogenic cell surface substrates of CK2α in the tumor microenvironment, showing that extracellular phosphorylation can generate immunogenic antigens.

Not dasycladalean alga, but an Odyssey of the earliest Phanerozoic animal reef-builders

The paper reclassifies Protomelission? sp. as archaeocyath-like sponges, challenging previous interpretations and providing insights into early animal reef-building.

Synthetic Biodegradable Void-forming Hydrogels for In Vitro 3D Culture of Functional Human Bone Cell Networks

This paper introduces a synthetic biodegradable hydrogel for 3D culture of human bone cells and analysis of secreted ECM, demonstrating rapid network formation and microfluidic integration.

Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

Alternative splicing of a potato disease resistance gene maintains homeostasis between development and immunity

The paper shows that the potato resistance gene RB uses alternative splicing to balance growth and immunity, with the pathogen effector IPI-O1 promoting splicing to enhance immunity.

Alteration of pro-carcinogenic gut microbiota is associated with clear cell renal cell carcinoma tumorigenesis

This study identifies associations between gut microbiota composition and serum metabolites with clear cell renal cell carcinoma, suggesting potential risk factors for tumorigenesis.

Mechanism of histone H2B monoubiquitination by Bre1

The paper reveals the mechanism by which Bre1 monoubiquitinates histone H2B, showing how its RING domains position Rad6 and contact DNA, and suggests a general mechanism for histone specificity.

Towards bone-remodeling-on-a-chip: self-assembling 3D osteoblast-osteoclast coculture in a microfluidic chip

This paper presents a 3D microfluidic coculture model of human bone remodeling using osteoblasts and osteoclasts, enabling long-term in vitro studies for drug testing.

A novel order-level lineage of ammonia-oxidizing Thaumarchaeota is widespread in marine and terrestrial environments

The paper identifies a new AOA order, Nitrosomirales, widespread in marine and terrestrial environments, showing metabolic versatility and horizontal gene transfer.

Evaluating the solubility of compounds intended for intramammary infusion based upon tests conducted across a range of milk products using cephapirin sodium and benzathine as model drugs

This paper evaluates drug solubility in milk products using cephapirin sodium and benzathine as model drugs, finding that whole milk or reconstituted milk can substitute for raw bovine milk for solubility assessments at 38°C.

Integrated Multi-omics Analyses of NFKB1 patients B cells points towards an up regula-tion of NF-κB network inhibitors

This study identifies epigenetic and gene expression changes in B cells from NFKB1 mutation carriers, highlighting dysregulation of NF-κB network inhibitors and potential therapeutic targets.

An exploratory study of a simple approach for evaluating drug solubility in milk related vehicles

This study evaluates a method for assessing drug solubility in various milk-related vehicles and finds that milk significantly enhances solubility of poorly water-soluble drugs, though the effect varies by drug.

Characterization of three-dimensional bone-like tissue growth and organization under influence of curvature and directional fluid flow

This study evaluates how curvature and directional fluid flow affect three-dimensional bone-like tissue growth and organization using human mesenchymal stromal cells in a concave channel scaffold.

A Unified Catalog of 19,251 Non-human Reference Species Genomes Provides New Insights into the Mammalian Gut Microbiomes

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

A Cambrian soft-bodied conical animal illustrates the origins of lophophorate phyla

The paper describes a Cambrian fossil with features of multiple lophophorate phyla, suggesting an intermediate evolutionary position between Phoronida and Brachiopoda.

An in vitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition

This study creates an in vitro fibrosis model using crosslinked native ECM hydrogels to alter biomechanics without changing composition, showing increased stiffness and fibroblast myofibroblastic differentiation.

Control of Leaf Width by the APC/CTAD1-WL1-NAL1 Pathway in Rice

This study identifies the APC/CTAD1-WL1-NAL1 pathway as a regulator of leaf width in rice and shows that mutations in WL1 lead to leaf width variation.

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

This study engineers SARS-CoV-2 neutralizing antibodies through directed evolution to enhance their potency and reduce viral escape.

A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 delta variant

This paper identifies two potent monoclonal antibodies from an Indian donor that neutralize SARS-CoV-2 variants including Delta, showing protection in a mouse model.

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

This study identifies nAbs against SIVmac239, reveals structural features of its Env trimer, and shows passive transfer of nAbs protects macaques from infection.

Light-induced Patterning of Electroactive Bacterial Biofilms

This paper develops a light-induced genetic circuit to pattern electroactive Shewanella oneidensis biofilms on electrodes, enabling tunable conductivity and confirming a collision-exchange electron transport mechanism.

A short prokaryotic argonaute cooperates with membrane effector to confer antiviral defense

The paper identifies a short prokaryotic argonaute (pAgo) in Sulfolobus islandicus that, along with Aga1 and Aga2, provides antiviral defense through abortive infection.

Effect of gastrointestinal alterations mimicking elderly conditions on in vitro digestion of meat and soy proteins

This study evaluates how in vitro digestion of meat and soy proteins differs under gastrointestinal conditions mimicking elderly achlorhydria compared to adults, showing reduced hydrolysis and distinct protein degradation patterns in elderly conditions.

Diversity, function and evolution of marine microbe genomes

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

Identification of electroporation sites in the complex lipid organization of the plasma membrane

This study identifies electroporation sites in the plasma membrane by combining simulations, machine learning, and Bayesian analysis, showing pores form in lipid domains with high polyunsaturated lipid density and depend on mechanical properties and electric field polarity.

Progressive chromatin silencing of ABA biosynthesis gene permits seed germination in Arabidopsis

The paper shows that RZ-1 and PRC2 work together to silence NCED6, a gene involved in ABA biosynthesis, which is essential for seed germination in Arabidopsis.