Cell cycle corruption in a preleukemic ETV6-RUNX1 model exposes RUNX1 addiction as a therapeutic target in acute lymphoblastic leukemia
J. P. Wray, E. M. Deltcheva, C. Boiers, S. E. Richardson, J. B. Chhetri, S. Gagrica, Y. Guo, A. Illendula, J. H. Martens, H. H. Stunnenberg, J. H. Bushweller, R. Nimmo, T. Enver
This study shows that RUNX1 addiction is a therapeutic target in acute lymphoblastic leukemia, as inhibiting RUNX1 activity spares normal hematopoiesis and affects multiple genetic subtypes.
bioRxiv · Dec 22, 2020 · PreprintCancer Biology