Author

I. Barbaric

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:cell type annotation· 6 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. Stavish· 7 shared C. J. Price· 5 shared O. Laing· 3 shared P. W. Andrews· 3 shared A. Tsakiridis· 2 shared P. J. Gokhale· 2 shared T. J. R. Frith· 2 shared A. Grierson· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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7 shared papersCell Biology

D. Stavish

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Aberrant Wnt activation in recurrent genetically variant human pluripotent stem cells impairs cardiomyocyte differentiation and phenotype

T. Wing, C. J. Price, D. Stavish, O. Laing, J. Riley, A. Lam, S. Oh, Y. Atlasi, I. Barbaric

This study shows that genetic variants in human pluripotent stem cells, specifically gains of chromosome 1q, impair cardiomyocyte differentiation and phenotype through aberrant Wnt activation.

bioRxiv · Dec 12, 2023 · PreprintCell Biology

Cytogenetic resource enables mechanistic resolution of changing trends in human pluripotent stem cell aberrations linked to feeder-free culture

D. Stavish, C. J. Price, G. Gelezauskaite, K. A. Leonhard, S. M. Taapken, E. M. McIntire, O. Laing, B. M. James, J. J. Riley, J. Zerbib, D. Baker, A. L. Harding, L. H. Jestice, T. F. Eleveld, A. J. M. Gillis, , I. Barbaric

The paper analyzes genetic changes in human pluripotent stem cells under different culture conditions and identifies a link between feeder-free culture and increased chromosome 1q gains.

bioRxiv · Sep 21, 2023 · PreprintCell Biology

A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations

I. M. Saldana-Guerrero, L. F. Montano-Gutierrez, K. Boswell, C. Hafemeister, E. Poon, L. E. Shaw, D. Stavish, R. A. Lea, S. Wernig-Zorc, E. Bozsaky, I. S. Fetahu, P. Zoescher, U. Pötschger, M. Bernkopf, A. Wenninger-Weinzierl, , F. Halbritter

The paper uses human embryonic stem cells to show that chromosomal gains in neuroblastoma impair neural crest development and enhance MYCN-driven tumourigenesis.

bioRxiv · Nov 21, 2022Cancer Biology

HDAC6 inhibition partially alleviates mitochondrial trafficking defects and restores motor function in human motor neuron and zebrafish models of Charcot-Marie-Tooth Disease Type 2A

L. Butler, K. I. Adamson, S. L. Johnson, L. Jestice, C. J. Price, D. Stavish, N. Pooranachandran, A. Tsakiridis, A. Grierson, I. Barbaric

This study shows HDAC6 inhibition improves mitochondrial trafficking and motor function in CMT2A models using human motor neurons and zebrafish.

bioRxiv · Jul 5, 2022 · PreprintCell Biology

Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition

C. J. Price, D. Stavish, P. J. Gokhale, S. Sargeant, J. Lacey, T. A. Rodriguez, I. Barbaric

This study shows genetically variant human pluripotent stem cells outcompete wild-type cells via YAP-mediated mechanisms leading to their elimination.

bioRxiv · Nov 25, 2019Cell Biology

Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells

J. A. Halliwell, T. J. R. Frith, C. J. Price, O. Laing, O. J. Bower, D. Stavish, P. Gokhale, Z. Hewitt, S. El-Khamisy, I. Barbaric, P. W. Andrews

This study shows that exogenous nucleosides reduce replication stress and genomic instability in human pluripotent stem cells by alleviating DNA damage and mitotic errors.

bioRxiv · Nov 23, 2019Cell Biology

Generation and Trapping of a Mesoderm Biased State of Human Pluripotency

D. Stavish, C. Boiers, C. Price, T. J. R. Frith, J. Halliwell, I. Barbaric, J. Brown, J. Carr, C. James, P. W. Andrews, T. Enver

The paper identifies and traps a mesoderm-biased pluripotent state in human stem cells using WNT signaling and lysophosphatidic acid.

bioRxiv · Oct 24, 2019Cell Biology