Huntingtin bundles and changes the local proteome of actin filaments in neurons
R. Carpentier, M. Capizzi, H. Kim, J. Novion-Ducassou, E. Denarier, B. Blot, Y. Coute, I. Arnal, J.-J. Song, S. Humbert
This study shows that Huntingtin (HTT) binds to F-actin, bundles actin filaments, and modulates the association of Drebrin1 with actin, affecting axonal growth and cytoskeletal organization in neurons.
bioRxiv · Aug 29, 2023Cell Biology