C. Chiozzini

Induction of SARS-CoV-2 N-specific CD8+ T cell immunity in lungs by engineered extracellular vesicles associates with strongly impaired viral replication

This study shows that engineered extracellular vesicles inducing N-specific CD8+ T cells in lungs reduce SARS-CoV-2 replication in mice, with effects lasting up to three months post-vaccination.

Strong SARS-CoV-2 N-specific CD8+ T immunity induced by engineered extracellular vesicles associates with protection from lethal infection in mice.

This paper shows engineered extracellular vesicles induce strong N-specific CD8+ T cell immunity in mice, which protects against lethal SARS-CoV-2 infection.

CD8+ T cell immunogenicity induced by endogenous EVs engineered by antigens fused to a truncated Nefmut EV-anchoring protein

This study shows that truncating the C-terminus of Nefmut does not reduce its ability to anchor antigens to EVs or induce CD8+ T cell immunity.

Long-term antitumor CD8+ T cell immunity induced by endogenously engineered extracellular vesicles

This paper demonstrates that engineered extracellular vesicles can induce long-term antitumor CD8+ T cell immunity against HPV16, effectively curing tumors and preventing relapse.

A new concept on anti-SARS-CoV-2 vaccines: strong CD8+ T-cell immune response in both spleen and lung induced in mice by endogenously engineered extracellular vesicles

This paper develops a DNA-based vaccine strategy using engineered extracellular vesicles to induce strong CD8+ T-cell immunity against SARS-CoV-2 in mice, with immune responses detected in both spleen and lung.