M. Sanchez

Switch-Like Phosphorylation of WRN Integrates End-Resection with RAD51 Metabolism at Collapsed Replication Forks

This study identifies phosphorylation events on WRN that regulate end-resection and RAD51-mediated repair at replication forks.

DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseases

This study demonstrates that DNA origami vaccine nanoparticles enhance both humoral and cellular immune responses against infectious diseases like SARS-CoV-2, HIV, and Ebola.

Unveiling Cryptosporidium parvum Sporozoite-Derived Extracellular Vesicles: Profiling, Origin, and Protein Composition

This study identifies and characterizes two types of extracellular vesicles from Cryptosporidium parvum sporozoites, revealing their unique protein compositions and potential roles in antigen presentation.

The cervical microbiota of Hispanics living in Puerto Rico is highly volatile and dominated by L. iners regardless of HPV status

The study examines the cervical microbiota of Hispanic women in Puerto Rico, finding it dominated by L. iners regardless of HPV status, with no significant microbiota-HPV associations.

Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype

The paper shows iron accumulation drives fibrosis, senescence, and SASP in mice and humans, and demonstrates MRI can detect fibrotic burden.

Strong SARS-CoV-2 N-specific CD8+ T immunity induced by engineered extracellular vesicles associates with protection from lethal infection in mice.

This paper shows engineered extracellular vesicles induce strong N-specific CD8+ T cell immunity in mice, which protects against lethal SARS-CoV-2 infection.

Identification of CRF66_BF, a new HIV-1 circulating recombinant form of South American origin

The paper identifies CRF66_BF, a new HIV-1 circulating recombinant form of South American origin, distinct from CRF12_BF and prevalent in Paraguay.

A cytofluorimetric analysis of a Saccharomyces cerevisiae population cultured in a fed-batch bioreactor

The paper uses flow cytometry to analyze the cell cycle of Saccharomyces cerevisiae during a fed-batch culture, using SYTOX Green and SYBR Green dyes to improve cycle stage definition.

Intercellular telomere transfer extends T cell lifespan

The paper shows T cells extend telomeres by acquiring telomere vesicles from APCs, independent of telomerase, thereby increasing their lifespan.

A genetic screen identifies new steps in oocyte maturation that enhance proteostasis in the immortal germ lineage

The paper identifies genes involved in oocyte maturation that enhance proteostasis in C. elegans germline through lysosomal acidification and mitochondrial functions.

Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting its Protein-Protein Interactions

This study develops peptide-based SHP2 inhibitors that target protein-protein interactions, showing higher affinity for pathogenic variants and efficacy in zebrafish embryos.

Validation of the Social Responsiveness Scale (SRS) to screen for atypical social behaviors in juvenile macaques

This study adapts and validates the Social Responsiveness Scale (SRS) for juvenile rhesus macaques to screen for atypical social behaviors, showing strong construct validity and sensitivity.

Crosstalk between eIF2α and eEF2 phosphorylation pathways optimizes translational arrest in response to oxidative stress

This study shows that oxidative stress causes translational arrest through eEF2 phosphorylation, not eIF2, and reveals crosstalk between eIF2 and eEF2 pathways in mouse cells.

Transient activation of the UPRER is an essential step in the acquisition of pluripotency during reprogramming

This study shows that transient activation of the UPRER is essential for successful reprogramming of somatic cells into pluripotency and can predict reprogramming efficiency.

A non-canonical arm of UPRER mediates longevity through ER remodeling and lipophagy.

This study identifies a non-canonical UPRER pathway that extends lifespan through ER remodeling and lipophagy, independent of chaperone function.

Phosphorylation By CK2 Regulates MUS81/EME1 In Mitosis And After Replication Stress

This study shows CK2 phosphorylates MUS81 at Serine 87 in mitosis and under replication stress, promoting its interaction with SLX4 and affecting chromosome stability.