Author

C. Coker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

N. Arpaia· 3 shared T. Danino· 3 shared R. L. Vincent· 2 shared A. A. Saleh· 1 shared A. Ahn· 1 shared A. Lim· 1 shared A. Redenti· 1 shared A. Sivan· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBioengineering

N. Arpaia

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Colorectal cancer detection and treatment with engineered probiotics

C. R. Gurbatri, G. Radford, L. Vrbanac, C. Coker, J. Im, S. R. Taylor, Y. Jang, A. Sivan, K. Rhee, A. A. Saleh, T. Chien, F. Zandkarimi, I. Lia, T. R. Lannagan, T. Wang, , T. Danino

This paper demonstrates the use of engineered probiotics to detect and treat colorectal cancer by monitoring their colonization and delivering therapeutic molecules.

bioRxiv · Apr 3, 2023 · PreprintBioengineering

Engineered bacteria recruit and orchestrate anti-tumor immunity

T. M. Savage, R. L. Vincent, S. S. Rae, L. H. Huang, A. Ahn, K. Pu, F. Li, C. Coker, T. Danino, N. Arpaia

The paper engineers bacteria to release chemokines that recruit immune cells into tumors, enhancing anti-tumor immunity in mouse models.

bioRxiv · Jun 16, 2022 · PreprintCancer Biology

Probiotic-guided CAR-T cells for universal solid tumor targeting

R. L. Vincent, C. Gurbatri, A. Redenti, C. Coker, N. Arpaia, T. Danino

This paper develops probiotic-guided CAR-T cells (ProCARs) that use synthetic antigens produced by tumor-colonizing bacteria to enhance T cell activation and tumor lysis in xenograft models.

bioRxiv · Oct 10, 2021 · PreprintBioengineering