Author

A. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Bioengineering· 2 Cell Biology· 2 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 5 Organism:mouse· 5 Approach:statistical model· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2

Frequent Co-Authors

M. L. Killian· 2 shared A. A. Saleh· 1 shared A. Chronopoulos· 1 shared A. del Rio Hernandez· 1 shared A. Farrugia· 1 shared A. G. Wise· 1 shared A. Hsieh· 1 shared A. J. Van Wettere· 1 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersPathology

M. L. Killian

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Author profile →

10 papers

Recent·Most cited

Programmed withdrawal of cilia maintenance followed by centriole capping leads to permanent cilia loss during cerebellar granule cell neurogenesis

S. Constable, C. M. Ott, A. L. Lemire, K. White, A. Lim, J. Lippincott-Schwartz, S. Mukhopadhyay

The paper identifies a programmed cilia deconstruction pathway in cerebellar granule cells during neurogenesis, showing decreased cilia maintenance and centriole capping prevent cilia regrowth and dysregulated signaling.

bioRxiv · Dec 7, 2023Cell Biology

Single-component multilayered self-assembling protein nanoparticles displaying extracellular domains of matrix protein 2 as a pan-influenza A vaccine

K. B. Gomes, Y.-N. Zhang, Y.-Z. Lee, M. Eldad, A. Lim, G. Ward, S. Auclair, L. He, J. Zhu

Single-component self-assembling protein nanoparticles displaying tandem M2e elicit robust and durable immunity against diverse influenza A viruses.

bioRxiv · Jun 2, 2023 · PreprintMicrobiology

Colorectal cancer detection and treatment with engineered probiotics

C. R. Gurbatri, G. Radford, L. Vrbanac, C. Coker, J. Im, S. R. Taylor, Y. Jang, A. Sivan, K. Rhee, A. A. Saleh, T. Chien, F. Zandkarimi, I. Lia, T. R. Lannagan, T. Wang, , T. Danino

This paper demonstrates the use of engineered probiotics to detect and treat colorectal cancer by monitoring their colonization and delivering therapeutic molecules.

bioRxiv · Apr 3, 2023 · PreprintBioengineering

Pathology of natural infection with highly pathogenic avian influenza virus (H5N1) clade 2.3.4.4b in wild terrestrial mammals in the United States in 2022

E. J. Elsmo, A. Wunschmann, K. B. Beckmen, L. B. Broughton-Neiswanger, E. L. Buckles, J. Ellis, S. D. Fitzgerald, R. Gerlach, S. Hawkins, H. Ip, J. Lankton, E. M. Lemley, J. Lenoch, M. L. Killian, K. Lantz, , A. Lim

The paper reports the first cases of H5N1 avian influenza in wild mammals in the US, showing neurological symptoms and lesions linked to bird-to-mammal spillover.

bioRxiv · Mar 10, 2023 · PreprintPathology

Automated Parallel Pattern Search Optimisation of Microfluidic Geometry for Extracellular Vesicle Liquid Biopsies

C. L. Hisey, A. Tyler, A. Lim, L. W. Chamley, C. Blenkiron, R. J. Clarke

The paper optimizes microfluidic geometry for extracellular vesicle capture using automated parallel pattern search, finding that larger pillars with spacing improve capture efficiency.

bioRxiv · Nov 13, 2021 · PreprintBioengineering

One Health Investigation of SARS-CoV-2 Infection and Seropositivity among Pets in Households with Confirmed Human COVID-19 Cases - Utah and Wisconsin, 2020

G. W. Goryoka, C. M. Cossaboom, R. Gharpure, P. Dawson, C. Tansey, J. Rossow, V. Mrotz, J. Rooney, M. Torchetti, C. M. Loiacono, M. L. Killian, M. Jenkins-Moore, A. Lim, K. Poulsen, D. Christensen, , C. Barton Behravesh

This study investigates SARS-CoV-2 infection and seropositivity in pets from households with confirmed human COVID-19 cases, finding that 17% of pets had neutralizing antibodies and suggesting transmission from humans to pets.

bioRxiv · Apr 11, 2021Microbiology

Description of Schaedlerella arabinophila gen. nov., sp. nov., a D-arabinose utilizing bacterium isolated from feces of C57BL/6J mice and a close relative of Clostridium sp. ASF 502

M. Soh, S. Miyake, A. Lim, H. Seedorf

The paper isolates and characterizes a new bacterial species, Schaedlerella arabinophila, closely related to Clostridium sp. ASF 502, from mouse feces and proposes its taxonomic reclassification.

bioRxiv · Dec 17, 2018Microbiology

N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

D. Kuppers, S. Arora, Y. Lim, A. Lim, L. Carter, P. Corrin, C. Plasier, R. Basom, J. Delrow, S. Wang, H. He, B. Torok-Storb, A. Hsieh, P. Paddison

The paper identifies m6A mRNA methylation as a regulator of erythropoiesis by promoting the translation of key genes involved in erythroid lineage specification.

bioRxiv · Oct 31, 2018Cell Biology

Genomic Surveillance for Antimicrobial Resistance in Mannheimia haemolytica Using Nanopore Single Molecule Sequencing Technology

A. Lim, B. Naidenov, H. Bates, K. Willyerd, T. Snider, M. B. Couger, C. Chen, A. Ramachandran

The paper uses nanopore sequencing to identify antimicrobial resistance genes in Mannheimia haemolytica strains and validates their resistance phenotypes.

bioRxiv · Aug 19, 2018 · PreprintMicrobiology

SREBP1 drives KRT80-dependent cytoskeletal changes and invasive behavior in endocrine resistant ERα breast cancer

L. Magnani, Y. Perone, A. Farrugia, A. Meira, B. Gyorffy, C. Ion, A. Uggetti, D. Patten, A. Chronopoulos, M. Faronato, S. Shousha, J. Steel, C. Davies, N. Patel, A. del Rio Hernandez, , F. Calvo

This study identifies SREBP1-driven KRT80 upregulation as a mechanism promoting invasion in endocrine-resistant ERα breast cancer through cytoskeletal changes and increased tumor stiffness.

bioRxiv · Jul 30, 2018Cancer Biology