Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting
E. Lee, C. Cullen, J. P. Murad, D. Gumber, A. Park, J. Yang, L. Stern, L. Adkins, G. Dhapola, B. Gittins, W.-C. Chang, C. Martinez, Y. Woo, M. Cristea, L. Rodriguez, , S. J. Priceman
This study develops TAG72-CAR T cells with antigen-dependent IL-12 signaling to enhance anti-tumor activity and systemic disease targeting in ovarian cancer.
bioRxiv · Jan 6, 2023 · PreprintCancer Biology