C. Cursi

SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP

This paper shows that SAMHD1 protects cells from dGTP toxicity caused by forodesine, and that forodesine can selectively kill SAMHD1-deficient leukemia cells.

Varicella-Zoster Virus ORF9 Is an Antagonist of the DNA Sensor cGAS

This study identifies ORF9 as a VZV protein that inhibits the cGAS/STING pathway, reducing type I IFN production during infection.