P. J. Kranzusch

This paper identifies bacterial SEA-like (SEAL) domains that undergo autoproteolysis and function in mechanotransduction, similar to eukaryotic SEA domains.

This study identifies CARD-like domains in bacterial defense systems that activate gasdermin-mediated cell death against phage infection.

The paper identifies mutations in phage virion assembly proteins that enable evasion of Type I CBASS immunity by altering infection kinetics.

This study determines the structure of a bacterial gasdermin pore and reveals a conserved mechanism of pore assembly and membrane targeting.

The paper identifies ABCF1, ABCF3, and Decr1 as 2'-5' OA binding proteins, showing evolutionary conservation and species-specific interactions, but finds no strong antiviral functions or translation regulation.

The paper determines the cryo-EM structure of the RADAR complex, showing RdrB targets mononucleotides and catalyzes ATP-to-ITP conversion to limit phage replication.

The paper identifies poxvirus-encoded proteins that impact inflammasome-mediated defenses through structural homology screens.

The paper identifies cGLRs as a widespread family of pattern recognition receptors in animal innate immunity and elucidates their conserved signaling mechanisms.

The paper identifies Tad1 proteins as inhibitors of TIR-domain signaling in bacterial antiphage systems, revealing gcADPR as the immune signaling molecule and its sequestration by Tad1.

The paper identifies three functional classes of cGAS proteins in mammals based on their self-DNA reactivity and interferon response mechanisms.

The paper characterizes a sequential C-to-U and U-to-Ψ RNA editing process in Vibrio cholerae tRNA mediated by TrcP, revealing its role in coupling tRNA modification states to iron availability.

This study identifies bacterial gasdermin homologs that execute prokaryotic cell death via caspase-like protease activation, revealing an ancient mechanism of regulated cell death shared with animals.

This study identifies ORF9 as a VZV protein that inhibits the cGAS/STING pathway, reducing type I IFN production during infection.

The paper characterizes NucC, a bacterial endonuclease activated by cyclic tri-AMP to mediate bacteriophage immunity through DNA cleavage or cell death.

The paper shows that the GacA enzyme in Geobacter sulfurreducens specifically regulates cGAMP levels to control metal reduction genes, despite in vitro promiscuity, through a kinetic model and structural analysis.