Author

A. Bridgeman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

J. Rehwinkel· 4 shared L. Chauveau· 2 shared R. E. Rigby· 2 shared A. Chabes· 1 shared A. Korning-Hvidt· 1 shared A. R. Townsend· 1 shared A. Schuh· 1 shared A. Townsend· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersImmunology

J. Rehwinkel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The RNA sensor MDA5 detects SARS-CoV-2 infection

N. G. Sampaio, L. Chauveau, J. Hertzog, A. Bridgeman, G. Fowler, J. P. Moonen, M. Dupont, R. A. Russel, M. Noerenberg, J. Rehwinkel

The paper identifies MDA5 as a cellular sensor for SARS-CoV-2 infection that induces type I and III interferons in Calu-3 cells.

bioRxiv · Mar 26, 2021Immunology

Recognition of Z-RNA by ADAR1 limits interferon responses

Q. Tang, R. E. Rigby, G. R. Young, A. Korning-Hvidt, T. K. Tang, A. Bridgeman, A. R. Townsend, G. Kassiotis, J. Rehwinkel

This study shows that ADAR1's Z domain prevents IFN responses by recognizing Z-RNA, and its absence leads to spontaneous IFN induction and improved viral control.

bioRxiv · Dec 4, 2020 · PreprintImmunology

SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP

T. Davenne, J. Klintman, S. Sharma, R. E. Rigby, C. Cursi, A. Bridgeman, B. Dadonaite, K. De Keersmaecker, P. Hillmen, A. Chabes, A. Schuh, J. Rehwinkel

This paper shows that SAMHD1 protects cells from dGTP toxicity caused by forodesine, and that forodesine can selectively kill SAMHD1-deficient leukemia cells.

bioRxiv · Feb 17, 2020Cancer Biology

cGAMP loading enhances the immunogenicity of VLP vaccines

L. Chauveau, A. Bridgeman, T. K. Tan, R. Beveridge, J. Frost, I. Pedroza-Pacheco, T. Partridge, P. Borrow, H. Drakesmith, A. Townsend, J. Rehwinkel

This study shows that incorporating cGAMP into virus-like particles (VLPs) enhances their immunogenicity, leading to stronger T cell responses and antibody titres against HIV and influenza viruses.

bioRxiv · Jan 3, 2020 · PreprintImmunology