Author

A. Schuh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:DNA methylation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Burns· 2 shared R. Clifford· 2 shared A. Blake· 1 shared A. Bridgeman· 1 shared A. Castor· 1 shared A. Chabes· 1 shared A. G. Abraham· 1 shared A. Ho· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

A. Burns

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Author profile →

5 papers

Recent·Most cited

Complex genotype-phenotype relationships shape the response to treatment of Down Syndrome Childhood Acute Lymphoblastic Leukaemia

C. Lutz, V. A. Turati, R. Clifford, P. S. Woll, T. Stiehl, A. Castor, S. A. Clark, H. Ferry, V. Buckle, A. Trumpp, A. Ho, A. Marciniak-Czochra, J. Herrero, A. Schuh, S. E. W. Jacobsen, T. Enver

This study investigates genotype-phenotype relationships in Down Syndrome ALL, showing that genetic and phenotypic heterogeneity influences treatment response and relapse through clonal competition.

bioRxiv · Feb 6, 2022Cancer Biology

Ligand-induced motions in pentameric ligand-gated ion channels revealed by EPR spectroscopy

V. Tiwari, J. S. Borchardt, A. Schuh, C. S. Klug, C. Czajkowski

This study uses EPR spectroscopy to reveal ligand-induced structural changes in the extracellular domain of GLIC, showing inward motions associated with agonist-induced closed pre-activated states.

bioRxiv · Nov 4, 2020 · PreprintBiophysics

TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes

M. Eyres, S. Lanfredini, A. Burns, A. Blake, F. Willenbrock, R. Goldin, D. Hughes, S. Hughes, A. Thapa, D. Valoulis, A. Hubert, Z. D'Costa, A. Sabbagh, A. G. Abraham, C. Blancher, , E. O'Neill

This study identifies TET2-driven 5hmc loss at GATA6 as a mechanism defining PDAC transcriptional subtypes and shows that TET2 stabilization with Metformin and Vitamin C reverses squamous-like tumor features.

bioRxiv · Oct 22, 2020Cancer Biology

SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP

T. Davenne, J. Klintman, S. Sharma, R. E. Rigby, C. Cursi, A. Bridgeman, B. Dadonaite, K. De Keersmaecker, P. Hillmen, A. Chabes, A. Schuh, J. Rehwinkel

This paper shows that SAMHD1 protects cells from dGTP toxicity caused by forodesine, and that forodesine can selectively kill SAMHD1-deficient leukemia cells.

bioRxiv · Feb 17, 2020Cancer Biology

The diagnostic chronic lymphocytic leukaemia genome by nanopore sequencing

A. Burns, D. Disalvo-Williams, D. Bruce, P. Robbe, A. Timbs, B. Stamatopoulos, R. Clifford, M. Lopopolo, D. Parkes, K. Ridout, A. Schuh

This paper presents a nanopore-based assay for CLL diagnostics, showing it can detect TP53 mutations, del17p13.1, and IgHV status in one run with high accuracy.

bioRxiv · Aug 28, 2019 · PreprintCancer Biology