Author

C. D. McDowell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:plant (other)· 2 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

I. Morozov· 4 shared J. A. Richt· 4 shared N. N. Gaudreault· 4 shared J. D. Trujillo· 3 shared T. Kwon· 3 shared D. A. Meekins· 2 shared D. Bold· 2 shared K. Cool· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

I. Morozov

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Author profile →

4 papers

Recent·Most cited

Pigs are highly susceptible to but do not transmit mink-derived highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b

T. Kwon, J. D. Trujillo, M. Carossino, E. L. Lyoo, C. D. McDowell, K. Cool, F. S. Matias-Ferreyra, T. Jeevan, I. Morozov, N. N. Gaudreault, U. Balasuriya, R. J. Webby, N. Osterrieder, J. A. Richt

Emerging Microbes & Infections · May 26, 2024Peer-reviewedMicrobiology

Gene editing of pigs to control influenza A virus infections

T. Kwon, B. Artiaga, C. D. McDowell, K. Whitworth, K. Wells, R. Prather, G. A. Delhon, M. Cigan, S. White, J. Retallick, N. N. Gaudreault, I. Morozov, J. A. Richt

This study edits pigs to knock out TMPRSS2, reducing influenza A virus replication and shedding, with implications for controlling IAV in pigs.

bioRxiv · Jan 15, 2024Microbiology

Susceptibility of sheep to experimental co-infection with the ancestral lineage of SARS-CoV-2 and its alpha variant

N. N. Gaudreault, K. Cool, J. D. Trujillo, I. Morozov, D. A. Meekins, C. D. McDowell, D. Bold, M. Carossino, V. Balaraman, D. Mitzel, T. Kwon, D. W. Madden, B. L. Artiaga, R. Pogranichniy, G. Roman-Sosa, , J. A. Richt

This study investigates sheep susceptibility to SARS-CoV-2 and finds that they show low susceptibility, with the alpha variant outcompeting the ancestral lineage.

bioRxiv · Nov 15, 2021Microbiology

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization

Y. Kim, N. N. Gaudreault, D. A. Meekins, K. D. Perera, D. Bold, J. D. Trujillo, I. Morozov, C. D. McDowell, K.-O. Chang, J. A. Richt

This study evaluates how mutations in SARS-CoV-2 Spike protein affect viral entry and neutralization across animal ACE2 receptors and identifies key mutations that enhance viral entry and reduce antibody neutralization.

bioRxiv · Aug 25, 2021Microbiology