The pleiotropic effects of the MNK1/2-eIF4E axis support immune suppression and metastasis in a model of postpartum breast cancer.
Q. Guo, M. Bartish, C. Goncalves, F. Huang, S. S. Krisna, S. Preston, A. Emond, V. Z. Li, C. Duerr, Y. Gui, A. Cleret-Buhot, P. Thebault, H. Lefrere, L. Lenaerts, D. Plourde, , W. H. Miller
This study shows that the MNK1/2-eIF4E axis promotes immune suppression and metastasis in postpartum breast cancer by affecting both tumor and non-tumor cells.
bioRxiv · Sep 7, 2020 · PreprintCancer Biology