F. Huang

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy

This study identifies PTPN2 as a therapeutic target in AML, discovers a selective inhibitor K73, and demonstrates its efficacy in reducing AML burden in vitro and in vivo.

Flexibility in the face of climate change? A rapid and dramatic shift toward later spring migration in Hudsonian Godwits (Limosa haemastica)

This study tracks shifts in Hudsonian godwit migration timing and finds a rapid 6-day delay with no sex differences, suggesting non-adaptive responses to climate change.

Human transmembrane protein 68 links triacylglycerol synthesis to membrane lipid homeostasis

This study identifies TMEM68 as a triacylglycerol synthase that regulates lipid metabolism and membrane lipid composition in neuro- and glioblastoma cells.

Hepatitis E virus infection upregulates ING5 expression in vitro and vivo

This study shows that HEV infection increases ING5 expression in both animal models and human cells, suggesting a potential role in HEV pathogenesis.

RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway

This study identifies RBM7 deficiency as a driver of breast cancer metastasis through MFGE8 splicing regulation and NF-kB pathway suppression.

Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia

This study shows vilazodone improves thrombocytopenia by activating SRC/MAPK signaling through 5-HT1A receptor in megakaryocyte differentiation.

Measurement precision bounds on aberrated single molecule emission patterns

This study quantifies the precision limits of position and wavefront distortion measurements in SMLM under various aberrations, providing theoretical guidelines for aberration correction.

Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice

This study shows that inhibiting PERK reduces autoimmune diabetes risk in mice by decreasing β cell immunogenicity and improving islet function.

Tunable PhenoCycler Imaging of the Murine Pre-Clinical Tumour Microenvironments

This study uses PhenoCycler imaging to analyze the tumor microenvironment in murine cancer models, revealing distinct TME features and cell-cell contact differences across cancer types.

Multi-omics map revealed PPARalpha activation protecting against myocardial ischemia-reperfusion injury by maintaining cardiac metabolic homeostasis

The paper identifies PPARalpha activation as protective against myocardial ischemia-reperfusion injury by maintaining cardiac metabolic homeostasis, using multi-omics data from rat hearts.

Comprehensive catalogs for microbial genes and metagenome-assembled genomes of the swine lower respiratory tract microbiome identify the relationship of microbial species with lung lesions

The paper constructs gene catalogs and metagenome-assembled genomes from the swine lower respiratory tract microbiome and identifies associations between microbial species and lung lesions.

Intrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly

The paper investigates the role of intrinsically disordered CsoS2 in α-carboxysome shell assembly using synthetic engineering and cryoEM structures, revealing its function as a molecular thread and identifying a conserved interaction motif.

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense

The paper identifies the Gabija complex's mechanism of sensing nucleotide depletion and executing DNA cleavage for antiviral defense, showing its unique synergy between GajA and GajB.

The central nervous system is a potential reservoir and possible origin of drug resistance in HBV

This study finds HBV can persist in cerebrospinal fluid, showing distinct mutations and resistance patterns compared to serum, and HIV co-infection increases resistance mutations in both compartments.

Real-Time Quantification of Cell Mechanics and Functions by Double Resonator Piezoelectric Cytometry -Theory and Study of Cellular Adhesion of HUVECs

This paper introduces DRPC to measure cell-generated forces and viscoelastic moduli in real time, showing ligand and cell density affect mechanical properties of HUVECs.

Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile

This study shows chloroquine induces eryptosis in P. falciparum-infected red blood cells, releasing EVs with unique proteomic profiles that may activate immune pathways.

Disrupting peroxisomes alters lipid metabolism in melanoma and uncovers a novel therapeutic vulnerability in combination with MAPK-targeted therapies

This paper identifies a metabolic vulnerability in melanoma cells by disrupting peroxisomes and shows that combining this with MAPK-targeted therapies enhances anti-tumor effects.

Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

This study shows that MFN2 deficiency leads to increased cytosolic Ca2+ and overactivation of RhoA and non-muscle myosin II, causing atypical peripheral actin band formation in mouse embryonic fibroblasts.

Meta-analysis refinement of plasma extracellular vesicle composition identifies proplatelet basic protein as a signaling messenger in type 1 diabetes

GIS-based approach and multivariate statistical analysis for identifying sources of heavy metals in marine sediments from the coast of Hong Kong.

The paper uses GIS and multivariate statistical methods to identify anthropogenic heavy metal sources in Hong Kong marine sediments, finding three distinct sources: industrial discharges, natural sources, and municipal/industrial wastewater.

Ubiquitin-like cGAS chain formation by a super enzyme activates anti-phage response

This study identifies a bacterial E2 enzyme that regulates cGAS by mimicking the ubiquitination cascade to activate anti-phage response through poly-cGASylation.

Glycopeptide antibiotic teicoplanin inhibits cell entry of SARS-CoV-2 by suppressing the proteolytic activity of cathepsin L

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

Chlamydomonas mutant hpm91 lacking PGR5 is a scalable and valuable strain for algal hydrogen (H2) production

The paper identifies hpm91, a Chlamydomonas mutant with high hydrogen production, as scalable and robust for large-scale algal H2 photoproduction.

P-TEFb is degraded by Siah1/2 in quiescent cells

This study identifies Siah1/2 as E3 ligases that degrade dissociated CycT1 in resting cells, preventing P-TEFb formation.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Biogenesis of a bacterial metabolosome for propanediol utilization

This study investigates the biogenesis of propanediol-utilization metabolosomes in bacteria, revealing both 'Shell first' and 'Cargo first' assembly pathways.

A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

Lung-selective Cas13d-based nanotherapy inhibits lethal SARS-CoV-2 infection by targeting host protease Ctsl

This paper develops a lung-selective Cas13d-based nanotherapy targeting Ctsl to inhibit SARS-CoV-2 infection, showing improved survival and reduced viral burden in mice.