Pharmacology & ToxicologybioRxiv
The development and characterization of an scFv-Fc fusion based gene therapy to reduce the psychostimulant effects of methamphetamine abuse
C. E. Hay, L. E. Ewing, M. D. Hambuchen…·E. C. Peterson
This paper develops and tests an scFv-Fc fusion antibody gene therapy for reducing methamphetamine's psychostimulant effects in mice, showing dose-dependent efficacy in locomotor and biodistribution studies.
DOI 10.1124/jpet.119.261180