Cancer BiologybioRxiv
A noncanonical FLT3 gatekeeper mutation disrupts gilteritinib binding and confers resistance
S. K. Joshi, S. Sharzehi, J. Pittsenbarger…·E. Traer
This study identifies a novel FLT3 mutation, N701K, that confers resistance to gilteritinib by blocking its binding, and suggests switching to type 2 FLT3 inhibitors may be effective.
DOI 10.1002/ajh.26174