Cancer BiologybioRxiv
Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy
A. F. Lingappa, O. Akintunde, C. Ewald…·V. R. Lingappa
The paper identifies two small molecules with pan-cancer cytotoxicity and validates their anti-tumor effects in xenograft models, showing they target TRIM28/KAP1-containing complexes involved in cancer survival.