Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy
A. F. Lingappa, O. Akintunde, C. Ewald, M. Froehlich, N. Ziari, M. Michon, S. F. Yu, S. Mallesh, J. Lin, A. Kitaygorodskyy, D. Solas, J. C. Reed, J. R. Lingappa, A. Mueller-Schiffmann, C. Korth, , V. R. Lingappa
The paper identifies two small molecules with pan-cancer cytotoxicity and validates their anti-tumor effects in xenograft models, showing they target TRIM28/KAP1-containing complexes involved in cancer survival.
bioRxiv · Sep 28, 2022Cancer Biology