D. Dey

An ALS Therapeutic Assembly Modulator Target in Peripheral Blood Mononuclear Cells: Implications for ALS Pathophysiology, Therapeutics, and Diagnostics

The paper identifies a multi-protein complex in PBMCs as a target for ALS therapeutic assembly modulators, showing altered composition in ALS patients and responsiveness to treatment.

The alphavirus TF protein plays a critical role in promoting viral propagation by altering cell-cell boundaries

This paper identifies the alphavirus TF protein's role in promoting viral propagation by altering cell-cell boundaries through downregulation of Scribble.

Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestration

Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition

This study optimizes berberine derivatives to create di-berberine conjugates that enhance aminoglycoside efficacy by inhibiting Pseudomonas aeruginosa MexY efflux pump function.

30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC

This paper determines the structure of RmtC bound to the 30S ribosomal subunit and identifies key residues involved in G1405 modification, providing insights for inhibitor development.

A single C-terminal residue controls SARS-CoV-2 spike trafficking and virion assembly

This study identifies a C-terminal residue critical for SARS-CoV-2 spike protein trafficking and virion assembly, offering insights for vaccine design.

Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy

The paper identifies two small molecules with pan-cancer cytotoxicity and validates their anti-tumor effects in xenograft models, showing they target TRIM28/KAP1-containing complexes involved in cancer survival.

Diffusion of small molecule drugs is affected by surface interactions and crowder proteins

This study examines how protein crowders affect the diffusion of small molecules, finding varied impacts based on molecular interactions and self-aggregation.

50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA

This paper reports the structure of the Mycobacterium tuberculosis TlyA enzyme bound to the 50S ribosomal subunit, revealing mechanisms of rRNA substrate recognition and modification that contribute to antibiotic resistance.

An Extended Motif in the SARS-CoV-2 Spike Modulates Binding and Release of Host Coatomer in Retrograde Trafficking

The paper identifies an extended COPI binding motif in the SARS-CoV-2 spike protein that modulates its interaction with COPI subunits and is critical for retrograde trafficking.

Targeted redesign of suramin analogs for novel antimicrobial lead development

This paper develops a computational framework to design suramin analogs with specific antiviral and antibacterial activity by virtual screening against viral and bacterial protein targets.

A Pan-respiratory Antiviral Chemotype Targeting a Host Multiprotein Complex

The paper identifies a novel antiviral chemotype effective against multiple respiratory viruses by targeting a host multi-protein complex involved in viral lifecycle and innate immunity.

An enhanced yeast display platform demonstrates the binding plasticity under various selection pressures

This paper enhances a yeast display platform with improved protein stability and fluorescence, demonstrating binding plasticity under different selection pressures.

Potential malaria vector Anopheles minimus (species A) still persisting in North East India

The study identifies the presence of Anopheles minimus sibling species A in NE India using morphological and molecular methods, highlighting its continued prevalence in endemic areas.

Line-FRAP, a versatile method based on fluorescence recovery after photobleaching to measure diffusion rates in vitro and in vivo

Line-FRAP measures diffusion rates in vitro and in vivo using confocal microscopy, showing slower diffusion in cells compared to buffer and osmotic pressure effects.

Overproduction of the AlgT sigma factor is lethal to mucoid Pseudomonas aeruginosa

This study shows that overproduction of AlgT sigma factor is lethal in mucoid Pseudomonas aeruginosa and identifies mutations in mucP as suppressors that stabilize MucA22 to reduce toxicity.

Understanding the adaptive evolution of mitochondrial genomes in intertidal chitons

This study investigates adaptive evolution in mitochondrial genomes of intertidal chitons by analyzing protein-coding genes and their functional implications in energy metabolism.

Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition

This study identifies functionally critical residues in RmtC that distinguish between 30S-binding affinity and 16S rRNA modification through structural and biochemical analysis.

Substrate recognition by the Pseudomonas aeruginosa EF-Tu methyltransferase EftM

This study defines the molecular mechanism of EF-Tu substrate recognition by the Pseudomonas aeruginosa methyltransferase EftM through computational modeling and experimental validation.

Phylogenetic, sequence and structural analysis of Insulin superfamily proteins reveals an indelible link between evolution and structure-function relationship

This study analyzes the evolution and structure-function relationship of insulin superfamily proteins, revealing high sequence conservation and structural constraints.