Author

D. Solas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

V. R. Lingappa· 3 shared A. F. Lingappa· 2 shared A. Kitaygorodskyy· 2 shared D. Dey· 2 shared J. C. Reed· 2 shared J. R. Lingappa· 2 shared M. Michon· 2 shared A. Mueller-Schiffmann· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

V. R. Lingappa

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

An ALS Therapeutic Assembly Modulator Target in Peripheral Blood Mononuclear Cells: Implications for ALS Pathophysiology, Therapeutics, and Diagnostics

S. Yu, M. Michon, A. F. Lingappa, K. Paulvannan, D. Solas, K. A. Staats, J. Ichida, D. Dey, J. Rosenfeld, V. R. Lingappa

The paper identifies a multi-protein complex in PBMCs as a target for ALS therapeutic assembly modulators, showing altered composition in ALS patients and responsiveness to treatment.

bioRxiv · Mar 28, 2024Physiology

Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy

A. F. Lingappa, O. Akintunde, C. Ewald, M. Froehlich, N. Ziari, M. Michon, S. F. Yu, S. Mallesh, J. Lin, A. Kitaygorodskyy, D. Solas, J. C. Reed, J. R. Lingappa, A. Mueller-Schiffmann, C. Korth, , V. R. Lingappa

The paper identifies two small molecules with pan-cancer cytotoxicity and validates their anti-tumor effects in xenograft models, showing they target TRIM28/KAP1-containing complexes involved in cancer survival.

bioRxiv · Sep 28, 2022Cancer Biology

Identification of an antiretroviral small molecule that appears to be a host-targeting inhibitor of HIV-1 assembly

J. C. Reed, D. Solas, A. Kitaygorodskyy, B. Freeman, D. T. B. Ressler, D. J. Phuong, J. V. Swain, K. Matlack, C. R. Hurt, V. R. Lingappa, J. R. Lingappa

This paper identifies two small molecules that inhibit HIV-1 assembly by targeting host factors involved in Gag assembly, showing efficacy against drug-resistant strains and lacking resistance mutations in Gag.

Journal of Virology · Jan 13, 2021Peer-reviewedMicrobiology