Mutation of lipoprotein processing pathway gene lspA or inhibition of LspA activity by globomycin increases MRSA resistance to beta-lactam antibiotics
C. Fingleton, M. S. Zeden, E. Bueno, F. Cava, J. P. O'Gara
This study shows that mutating lspA or inhibiting LspA with globomycin increases MRSA resistance to beta-lactam antibiotics by affecting cell envelope components beyond peptidoglycan.
bioRxiv · Feb 3, 2021 · PreprintMicrobiology