J. Clarke

Prebiotic proanthocyanidins inhibit bile reflux-induced esophageal adenocarcinoma through reshaping the gut microbiome and esophageal metabolome

This study shows that prebiotic proanthocyanidins inhibit reflux-induced esophageal adenocarcinoma by altering gut microbiome and esophageal metabolome, reducing inflammation and cellular damage.

Faecal glucocorticoid metabolite levels of intensive captive, free-range captive, and wild Tasmanian devils

The paper compares faecal glucocorticoid metabolite levels in intensive captive, free-range captive, and wild Tasmanian devils to assess stress physiology differences.

Survival of mineral-bound peptides into the Miocene

This study shows that peptide sequences from ostrich eggshells survived for 6.5-9 million years, extending the known preservation of ancient proteins to the Miocene.

Diversity, abundance, and host specificity of the human skin associated circular and single stranded DNA virome

The paper characterizes the circular single-stranded DNA virome of human skin, identifying novel viruses and revealing their host range and sequence stability.

A wheat kinase and immune receptor form the host-specificity barrier against the blast fungus

The paper identifies two wheat resistance genes that act as host-specificity barriers against the blast fungus and describes assays to incorporate these genes into wheat cultivars.

Feline Papillomavirus Isolate P20 Assembled from Metagenomic Data Isolated from the Human Skin of a House Cat Owner

The paper assembles a feline papillomavirus isolate from human skin metagenomic data and describes its genome characteristics.

The Application of The Skin Virome for Human Identification

This study evaluates the stability and diversity of the human skin virome as a tool for human identification, identifying 59 stable viral markers across three body locations over six months.

Pollen source richness may be a poor predictor of bumblebee colony growth

This study shows that bumblebee colonies fed a monofloral pollen diet with higher protein content outperformed those on a polyfloral diet, challenging the assumption that floral richness benefits colony growth.

The folding and unfolding behavior of ribonuclease H on the ribosome

This study investigates how the ribosome affects the folding and unfolding of RNase H during translation, finding that ribosome-stalled RNase H unfolds faster but maintains the same folding rate.

Vitamin D regulates MerTK-dependent phagocytosis in human myeloid cells

This study shows that vitamin D reduces MerTK expression in myeloid cells, inhibiting phagocytosis and potentially reducing inflammation in multiple sclerosis.

CD4+ follicular helper-like T cells are key players in anti-tumor immunity

The paper identifies CD4+ follicular helper-like T cells as critical for enhancing anti-tumor CD8+ T cell responses and tumor growth inhibition.

Impaired alanine transport or exposure to D-cycloserine increases the susceptibility of MRSA to beta-lactam antibiotics

The paper shows that impairing alanine transport or exposing MRSA to D-cycloserine increases susceptibility to beta-lactam antibiotics by reducing peptidoglycan crosslinking.

Establishing the phenotypic basis of adherent-invasive Escherichia coli (AIEC) pathogenicity in intestinal inflammation

This study investigates AIEC pathogenicity in intestinal inflammation by linking in vitro phenotypes to in vivo disease severity in a murine model.

Spontaneous oligomerization of BAK/BAX is suppressed by hetero-dimerization with MCL-1

This study shows that BAK/BAX spontaneous oligomerization is suppressed by MCL-1 hetero-dimerization, with BH3-only proteins disrupting these interactions to promote apoptosis.

Streptolysin production and activity is central to in vivo pathotype and disease outcome in GAS infections

This study shows that streptolysin O (SLO) production and activity determine the pathotype and disease outcome in Group A Streptococcus (GAS) infections, with implications for therapeutic strategies.

Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs

The paper identifies Affimer reagents that selectively bind BCL-2 family proteins through non-canonical structural motifs, showing competitive inhibition and conformational changes.

Adaptation of proteins to the cold in Antarctic fish: A role for Methionine?

This study compares the amino acid composition of proteins in Antarctic notothenioid fish and temperate teleosts, finding a significant over-representation of methionine in notothenioid orthologues, suggesting a potential redox sensing role.

The Folding Pathway of an Ig Domain is Conserved On and Off the Ribosome

The paper shows that the folding pathway of the titin I27 domain is conserved whether folding occurs on or off the ribosome.

A gut pathobiont synergizes with the microbiota to instigate inflammatory disease marked by immunoreactivity against other symbionts but not itself

This study shows that a gut pathobiont, H. bilis, synergizes with the microbiota to cause inflammation, triggering a Th17 response against other microbes rather than itself.