E. Bueno

Staphylococcus aureus counters organic acid anion-mediated inhibition of peptidoglycan cross-linking through robust alanine racemase activity

This study shows that Staphylococcus aureus counters acetate-mediated inhibition of peptidoglycan cross-linking by maintaining high intracellular D-Ala levels through alanine racemase and limiting D-Ala flux via D-alanine aminotransferase.

Metabolic reprogramming and flux to cell envelope precursors in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics

This study shows that mutating the pentose phosphate pathway gene pgl in MRSA increases resistance to beta-lactam antibiotics through metabolic reprogramming and changes in cell envelope precursors.

Transient glycolytic complexation of arsenate enhances resistance in the enteropathogen Vibrio cholerae

This study identifies a novel arsenate resistance mechanism in V. cholerae involving the formation of a transient glycolytic complex to sequester arsenate and prevent its toxic effects.

Candidate undecaprenyl phosphate translocases enable conditional microbial fitness and pathogenesis

The paper identifies DUF368-containing proteins as undecaprenyl phosphate translocases essential for bacterial alkaline fitness and pathogenesis in Vibrio cholerae and Staphylococcus aureus.

Mutation of lipoprotein processing pathway gene lspA or inhibition of LspA activity by globomycin increases MRSA resistance to beta-lactam antibiotics

This study shows that mutating lspA or inhibiting LspA with globomycin increases MRSA resistance to beta-lactam antibiotics by affecting cell envelope components beyond peptidoglycan.

Genetic dissection of the fermentative and respiratory contributions supporting Vibrio cholerae hypoxic growth

This study identifies genetic factors enabling Vibrio cholerae to grow under hypoxia by combining fermentation and NO3- respiration, revealing interactions between these pathways.

The spore of the beans: Spatially explicit models predict coffee rust spread in fragmented landscapes

The paper models coffee rust spread in fragmented landscapes, finding that coffee plant clustering is the main driver of rust transmission, with deforestation exacerbating outbreaks in clustered landscapes.