Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque
J. Schmidt, R. Wilson, B. Davenport, T. Hacker, C. Fitz, H. A. Simmons, M. L. Schotzko, T. Golos, H. Jones
This study delivers hIGF1-loaded nanoparticles to the placenta of a pregnant rhesus macaque via uterine artery catheterization, showing successful placental uptake and expression of hIGF1.
bioRxiv · Apr 10, 2024Physiology