Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL
A. Sethi, C. R. Horne, C. Fitzgibbon, K. L. Wilde, K. A. Davies, S. E. Garnish, A. V. Jacobsen, A. L. Samson, J. L. Hildebrand, A. Wardak, P. E. Czabotar, E. J. Petrie, P. R. Gooley, J. M. Murphy
The paper identifies distinct membrane binding epitopes in mouse and human MLKL orthologs that mediate necroptosis, revealing differences in their structural and functional mechanisms.
bioRxiv · May 3, 2021Cell Biology