Author

A. L. Samson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2

Frequent Co-Authors

J. M. Murphy· 5 shared C. Hall· 3 shared C. R. Horne· 3 shared S. Chiou· 3 shared S. E. Garnish· 3 shared A. Hempel· 2 shared A. Jacobsen· 2 shared A. V. Jacobsen· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersCell Biology

J. M. Murphy

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Author profile →

5 papers

Recent·Most cited

An immunohistochemical atlas of necroptotic pathway expression

S. Chiou, A. Al-Ani, Y. Pan, K. Patel, I. Kong, L. Whitehead, A. Light, S. Young, M. Barrios, C. Sargeant, P. Rajasekhar, L. Zhu, A. Hempel, A. Lin, J. Rickard, , A. L. Samson

The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.

bioRxiv · Oct 31, 2023Cell Biology

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

E. C. Tovey, S. E. Garnish, J. Day, H. Anderton, S. Chiou, A. Hempel, C. Hall, K. Patel, P. Gangatirkar, C. S. N. Li Wai Suen, A. Garnham, A. J. Kueh, U. Nachbur, A. L. Samson, J. M. Murphy, J. M. Hildebrand

This study shows that MLKL deficiency reduces age-related sterile inflammation in mice by preserving lymphocyte levels and reducing inflammatory infiltrates in tissues.

bioRxiv · Oct 17, 2022 · PreprintImmunology

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

S. E. Garnish, K. R. Martin, M. Kauppi, V. Jackson, R. Ambrose, V. V. Eng, S. Chiou, Y. Meng, D. Frank, E. C. Tovey Crutchfield, K. M. Patel, A. Jacobsen, G. Atkin-Smith, L. Di Rago, M. Doerflinger, , J. Hildebrand

The paper shows that a common MLKL polymorphism, S132P, enhances necroptotic activity in human cells and impairs recovery from infection in mice.

bioRxiv · Sep 8, 2022 · PreprintImmunology

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL

A. Sethi, C. R. Horne, C. Fitzgibbon, K. L. Wilde, K. A. Davies, S. E. Garnish, A. V. Jacobsen, A. L. Samson, J. L. Hildebrand, A. Wardak, P. E. Czabotar, E. J. Petrie, P. R. Gooley, J. M. Murphy

The paper identifies distinct membrane binding epitopes in mouse and human MLKL orthologs that mediate necroptosis, revealing differences in their structural and functional mechanisms.

bioRxiv · May 3, 2021Cell Biology

A toolbox for imaging RIPK1, RIPK3 and MLKL in mouse and human cells

A. L. Samson, C. Fitzgibbon, K. M. Patel, J. M. Hildebrand, L. Whitehead, J. S. Rimes, A. V. Jacobsen, C. R. Horne, X. J. Gavin, S. N. Young, K. L. Rogers, E. D. Hawkins, J. M. Murphy

This paper provides validated antibodies for detecting RIPK1, RIPK3, and MLKL in mouse and human cells, showing that methanol fixation is better than paraformaldehyde for immunofluorescence.

bioRxiv · Oct 26, 2020Cell Biology