L. Whitehead

Spatial analysis of Hofbauer cell transcriptome, distribution and morphology in placentas exposed to Plasmodium falciparum

The paper examines spatial transcriptomic and proteomic profiles of Hofbauer cells in placentas with and without past Plasmodium falciparum infection, finding no significant differences in HBC features but reduced fetal vessel development in infected placentas.

An immunohistochemical atlas of necroptotic pathway expression

The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.

Divergent roles for caspase-8 and MLKL in high-fat diet induced obesity and NAFLD in mice

This study investigates the distinct roles of caspase-8 and MLKL in high-fat diet-induced obesity and NAFLD in mice, showing that MLKL contributes to disease independently of inflammation.

SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine

This study shows that SOCS2's regulation of growth hormone signaling depends on its interaction with phosphotyrosine, as demonstrated by comparing Socs2R96C/R96C and Socs2-/- mice.

The minor spliceosome offers a therapeutically viable target for the treatment of a broad spectrum of cancers

This study shows that targeting the minor spliceosome, specifically Rnpc3, reduces tumor burden in multiple cancer models and is associated with poor patient survival in cancer transcriptomes.

Elys deficiency constrains Kras-driven tumour burden by amplifying oncogenic stress

The paper shows that reducing Elys function in a zebrafish model of Kras-driven liver cancer reduces tumour burden by inducing DNA damage and cell death.

Real-Time Multi-Angle Projection Imaging of Biological Dynamics

This paper introduces a projection imaging method that enables real-time, multi-angle visualization of biological processes with reduced data overhead.

A toolbox for imaging RIPK1, RIPK3 and MLKL in mouse and human cells

This paper provides validated antibodies for detecting RIPK1, RIPK3, and MLKL in mouse and human cells, showing that methanol fixation is better than paraformaldehyde for immunofluorescence.

BCL-XL is essential for the protection from secondary anemia caused by radiation-induced fatal kidney damage

The paper shows that BCL-XL protects adult kidneys from radiation-induced damage, leading to secondary anemia, and highlights its importance in cancer therapy combinations.

Vasoactive intestinal peptide confers anticipatory mucosal immunity by regulating ILC3 activity

This study shows that vasoactive intestinal peptide (VIP) regulates ILC3 activity to enhance IL-22 production and confer gut protection through the VIP-VIPR2 pathway.

Toxoplasma gondii bradyzoites induce transcriptional changes to host cells and prevent IFNγ-mediated cell death

This study shows that Toxoplasma gondii bradyzoites alter host cell transcription and prevent IFNγ-mediated cell death through protein export.