Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
14 papers
Recent·Most cited
S. Chiou, A. Al-Ani, Y. Pan, K. Patel, I. Kong, L. Whitehead, A. Light, S. Young, M. Barrios, C. Sargeant, P. Rajasekhar, L. Zhu, A. Hempel, A. Lin, J. Rickard, , A. L. Samson
The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.
bioRxiv · Oct 31, 2023Cell Biology
K. T. Reid, S. J. Colpitts, J. A. Mathews, A. S. Carreira, J. M. Murphy, D. T. Borovsky, W. Cui, T. A. Moya, N. Sachewsky, J. An, Y. Xia, A. Mortha, J. B. Lee, L. Zhang, I. Novitzky-Basso, , S. Q. Crome
This study demonstrates that IL-10-producing group 2 innate lymphoid cells (ILC210) can suppress Graft-versus-Host Disease (GVHD) in a humanized model without compromising graft-versus-leukemic effects.
bioRxiv · Aug 21, 2023Immunology
H. Tye, S. A. Conos, T. M. Djajawi, N. Abdoulkader, I. Y. Kong, H. L. Kaummon, V. K. Narayana, M. Speir, T. A. Gottschalk, J. Emery, D. S. Simpson, C. Hall, A. J. Vince, S. Russo, R. Crawley, , K. Lawlor
This study investigates the distinct roles of caspase-8 and MLKL in high-fat diet-induced obesity and NAFLD in mice, showing that MLKL contributes to disease independently of inflammation.
bioRxiv · Mar 14, 2023Immunology
E. C. Tovey, S. E. Garnish, J. Day, H. Anderton, S. Chiou, A. Hempel, C. Hall, K. Patel, P. Gangatirkar, C. S. N. Li Wai Suen, A. Garnham, A. J. Kueh, U. Nachbur, A. L. Samson, J. M. Murphy, J. M. Hildebrand
This study shows that MLKL deficiency reduces age-related sterile inflammation in mice by preserving lymphocyte levels and reducing inflammatory infiltrates in tissues.
bioRxiv · Oct 17, 2022 · PreprintImmunology
S. E. Garnish, K. R. Martin, M. Kauppi, V. Jackson, R. Ambrose, V. V. Eng, S. Chiou, Y. Meng, D. Frank, E. C. Tovey Crutchfield, K. M. Patel, A. Jacobsen, G. Atkin-Smith, L. Di Rago, M. Doerflinger, , J. Hildebrand
The paper shows that a common MLKL polymorphism, S132P, enhances necroptotic activity in human cells and impairs recovery from infection in mice.
bioRxiv · Sep 8, 2022 · PreprintImmunology
S. A. Jamieson, M. Pudjihartono, C. Horne, R. C. Day, J. M. Murphy, P. D. Mace
This study identifies nanobodies that recognize an activated conformation of TRIB2 pseudokinase, revealing structural insights and potential for inhibitor development.
bioRxiv · Apr 29, 2022Biochemistry
C. M. McEvoy, J. M. Murphy, L. Zhang, S. Clotet-Freixas, J. A. Mathews, J. An, M. Karimzadeh, D. Pouyabahar, S. Su, O. Zaslaver, H. Rost, M. Arambewela, L. Y. Liu, S. Zhang, K. A. Lawson, , S. Q. Crome
This study profiles healthy human kidney cells from 19 donors to reveal sex-based transcriptional differences and tissue-specific immune features.
bioRxiv · Dec 9, 2021Immunology
A. Sethi, C. R. Horne, C. Fitzgibbon, K. L. Wilde, K. A. Davies, S. E. Garnish, A. V. Jacobsen, A. L. Samson, J. L. Hildebrand, A. Wardak, P. E. Czabotar, E. J. Petrie, P. R. Gooley, J. M. Murphy
The paper identifies distinct membrane binding epitopes in mouse and human MLKL orthologs that mediate necroptosis, revealing differences in their structural and functional mechanisms.
bioRxiv · May 3, 2021Cell Biology
S. Vijayaraj, R. Feltham, M. Rashidi, D. Frank, Z. Liu, D. Simpson, G. Ebert, A. Vince, M. J. Herold, A. J. Kueh, J. Pearson, L. Dagley, J. M. Murphy, A. I. Webb, K. E. Lawlor, J. E. Vince
This study shows that IL-1β is ubiquitylated and degraded to limit its inflammatory activity, with specific ubiquitin modifications and electrostatic interactions playing key roles.
bioRxiv · Mar 15, 2021 · PreprintImmunology
A. L. Samson, C. Fitzgibbon, K. M. Patel, J. M. Hildebrand, L. Whitehead, J. S. Rimes, A. V. Jacobsen, C. R. Horne, X. J. Gavin, S. N. Young, K. L. Rogers, E. D. Hawkins, J. M. Murphy
This paper provides validated antibodies for detecting RIPK1, RIPK3, and MLKL in mouse and human cells, showing that methanol fixation is better than paraformaldehyde for immunofluorescence.
bioRxiv · Oct 26, 2020Cell Biology
S. Kumar, Y. Lim, D. De Bellis, J. J. Sandow, L. Capalbo, P. P. D'Avino, J. M. Murphy, A. I. Webb, L. Dorstyn
This study identifies Aurora B kinase-mediated phosphorylation of caspase-2 at S384, which inhibits its catalytic activity and apoptosis function during mitotic catastrophe.
bioRxiv · Mar 5, 2020Cell Biology
S. J. Trevelyan, J. L. Brewster, A. E. Burgess, J. M. Crowther, A. L. Cadell, B. L. Parker, D. R. Croucher, R. C. Dobson, J. M. Murphy, P. D. Mace
This study identifies the mechanism by which ASK1-3 kinases form preferential heterocomplexes through their SAM domains, revealing structural insights into their role in inflammatory signaling.
bioRxiv · Jul 5, 2019Biochemistry
L. Mahdi, M. Huang, X. Zhang, R. T. Nakano, L. B. Kopp, I. M. L. Saur, F. Jacob, V. Kovacova, D. Lapin, J. E. Parker, J. M. Murphy, K. Hofmann, P. Schulze-Lefert, J. Chai, T. Maekawa
The paper identifies a plant MLKL protein family structurally similar to vertebrate MLKL, which provides immunity against pathogens without inducing cell death.
bioRxiv · Jun 25, 2019 · PreprintPlant Biology
E. A. DeRiso, A. L. Szymczak-Workman, A. Montecalvo, J. M. Murphy, M.-C. Seminario, L. P. Kane, S. C. Bunnell
This study shows NEMO is recruited into TCR microclusters via polyubiquitin recognition domains, requiring Lck and ZAP-70 but not LAT or SLP-76.
bioRxiv · Apr 30, 2019 · PreprintImmunology