BiochemistrybioRxiv
Triple-action inhibitory mechanism of allosteric TYK2-specific inhibitors
J. Wang, V. S. Batista, C. G. Bunick
This paper investigates the triple-action inhibitory mechanism of deucravacitinib on TYK2, revealing its inhibition in three distinct states and structural basis for selectivity.
DOI 10.1016/j.jid.2025.04.025