Cell BiologyJournal of Biological ChemistryPeer-reviewed
Cleavage of protein kinase c δ by caspase-3 mediates pro-inflammatory cytokine-induced apoptosis in pancreatic islets
J. Collins, R. A. Piscopio, M. E. Reyland…·N. L. Farnsworth
This study identifies PKCδ's role in cytokine-induced apoptosis in pancreatic β-cells, showing that caspase-3 cleavage and nuclear translocation of PKCδ are required for cytokine-mediated β-cell death.
DOI 10.1016/j.jbc.2024.107611