J. Collins

Cleavage of protein kinase c δ by caspase-3 mediates pro-inflammatory cytokine-induced apoptosis in pancreatic islets

This study identifies PKCδ's role in cytokine-induced apoptosis in pancreatic β-cells, showing that caspase-3 cleavage and nuclear translocation of PKCδ are required for cytokine-mediated β-cell death.

Peptide Coated Polycaprolactone-Benzalkonium Chloride Nanocapsules for Targeted Drug Delivery to the Pancreatic β-Cell

This paper develops peptide-coated nanocapsules for targeted drug delivery to pancreatic β-cells, showing effective in vitro and in vivo targeting and cargo delivery.

Divergent C. elegans toxin alleles are suppressed by distinct mechanisms

The paper identifies a new TA system in C. elegans with divergent toxin alleles suppressed by distinct mechanisms, including piRNA-mediated silencing in the N2 haplotype.

Chromosome-scale genome assembly of bread wheat's wild relative Triticum timopheevii

This study presents a chromosome-scale genome assembly of Triticum timopheevii using PacBio HiFi and Hi-C data, revealing genomic features and relationships between wheat genomes.

The microbial metabolite Urolithin A reduces C. difficile toxin expression and repairs toxin-induced epithelial damage.

This study shows that urolithin A reduces C. difficile toxin production and repairs epithelial damage in a preclinical colitis model.

Distinct patterns of genetic variation at low-recombining genomic regions represent haplotype structure

The paper identifies distinct genetic variation patterns in low-recombining regions of Eurasian blackcap genomes, attributing them to reduced recombination rates rather than selection.

Convergent evolution of genome guardian functions in a parasite-specific p53 homolog

This study investigates two P53 homologs in Schistosoma mansoni, finding one orthologous to canonical P53 and another parasite-specific paralog involved in genotoxic stress response, suggesting convergent evolution.

Fenbendazole resistance in Heterakis gallinarum, the vector of Histomonas meleagridis, the causative agent of Blackhead Disease in poultry.

This study shows that Heterakis gallinarum has developed resistance to fenbendazole, reducing its effectiveness in controlling the nematode and potentially allowing Histomonas meleagridis to spread in poultry.

Impact of fenbendazole resistance in Ascaridia dissimilis on the economics of production in turkeys

This study shows that fenbendazole-resistant Ascaridia dissimilis in turkeys reduces feed conversion efficiency, leading to economic losses despite low worm burdens.

AMiGA: software for automated Analysis of Microbial Growth Assays

AMiGA automates the analysis of microbial growth assays, estimating growth parameters and testing differential growth without assuming growth curve shapes.

A single-cell RNAseq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding

This study uses single-cell RNAseq to analyze adult Schistosoma mansoni parasites, identifying a key regulator of blood feeding and gut maintenance.

SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways

This study shows SOX21 inhibits SOX2-driven differentiation of airway progenitor cells in mice and humans, maintaining epithelial cell balance during development and regeneration.

Identification of simplified microbial communities that inhibit Clostridioides difficile infection through dilution/extinction

The paper identifies simplified microbial communities that inhibit C. difficile infection through dilution/extinction and tests their efficacy in a mouse model.

Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni

This study performs a large-scale RNAi screen in Schistosoma mansoni to identify therapeutic targets, finding genes involved in neuromuscular function, tissue integrity, and parasite survival.

Deep Learning for RNA Synthetic Biology

The paper uses deep neural networks to predict toehold switch function in RNA synthetic biology, outperforming existing models and providing visual insights into their behavior.

Computationally guided high-throughput design of self-assembling drug nanoparticles

This paper develops a high-throughput screening platform with machine learning to design self-assembling drug nanoparticles, identifying 101 novel formulations from 2.1 million combinations.

Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite Schistosoma mansoni

The paper improves in vitro culture conditions for Schistosoma mansoni, enabling sustained egg production and revealing male-induced female maturation and a novel nuclear receptor involved in sexual development.