C. Galli

FAM134B regulates ER-to-lysosome-associated degradation of misfolded proteins upon pharmacologic or genetic inactivation of ER-associated degradation

The paper shows that ERLAD compensates for ERAD dysfunction by delivering misfolded proteins to lysosomes when ERAD is inhibited.

Optical modulation of excitation-contraction coupling in human induced pluripotent stem cell-derived cardiomyocytes

This study uses a photoswitch to optically modulate electrical activity and contractility in human induced pluripotent stem cell-derived cardiomyocytes.

LIS1, a glyco-humanized swine polyclonal anti-lymphocyte globulin, as a novel induction treatment in solid organ transplantation

The paper describes LIS1, a glyco-humanized anti-lymphocyte globulin, as a novel induction therapy for solid organ transplantation that reduces immunogenicity and T-cell depletion while maintaining immunosuppression.

SEC62 and TMX4 control asymmetric autophagy of the nuclear envelope upon LINC complex disassembly

The paper identifies SEC62 and TMX4 as regulators of asymmetric autophagy of the nuclear envelope during LINC complex disassembly in response to ER homeostatic changes.

Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros

The paper generates and characterizes induced pluripotent stem cells (iPSCs) from the Sumatran rhinoceros to aid in conservation efforts.

High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2

This paper describes the development of glyco-humanized swine polyclonal antibodies (GH-pAb) that neutralize SARS-CoV-2 with high potency and safety, and suggests clinical evaluation of the antibody XAV-19.

Mesoscale Dynamics of Spectrin and Acto-Myosin shape Membrane Territories during Mechanoresponse

The paper investigates how spectrin and acto-myosin cytoskeletons dynamically reorganize during mechanical challenges to support membrane territories.