S. Brouard

The immune profile of circulating autoreactive CD4 T cells is imprinted through tissue activation during autoimmune liver diseases

This study identifies the transcriptional profile of circulating autoreactive CD4 T cells in autoimmune liver diseases and shows their functional relationship to liver-specific pathogenic clones.

A gene-expression module in circulating immune cells is associated with cell migration during immune diseases.

The paper identifies a gene expression module in circulating immune cells linked to migration during immune diseases and shows its role in tissue recruitment and immune activation.

LIS1, a glyco-humanized swine polyclonal anti-lymphocyte globulin, as a novel induction treatment in solid organ transplantation

The paper describes LIS1, a glyco-humanized anti-lymphocyte globulin, as a novel induction therapy for solid organ transplantation that reduces immunogenicity and T-cell depletion while maintaining immunosuppression.

Preclinical model for the study of immune responses specific for a hepatic self-antigen

This paper develops a murine model to study antigen-specific CD4+ T cell responses in the liver, showing that antigen expression under different inflammatory conditions leads to distinct immune outcomes.

High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2

This paper describes the development of glyco-humanized swine polyclonal antibodies (GH-pAb) that neutralize SARS-CoV-2 with high potency and safety, and suggests clinical evaluation of the antibody XAV-19.

Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

The paper characterizes autoreactive CD4 T cells in autoimmune hepatitis patients, identifying a specific phenotype linked to disease activity and IgG response.