Cancer BiologybioRxiv
Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers
N. Chatterjee, E. Pazarentzos, G. Hrustanovic…·T. G. Bivona
The paper identifies PDHK1 as a synthetic-essential gene in PTEN-deficient cells and cancers, showing its upregulation drives aerobic glycolysis and correlates with poor patient survival.
DOI 10.1016/j.celrep.2019.07.063