Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers
N. Chatterjee, E. Pazarentzos, G. Hrustanovic, L. Lin, E. Verschueren, J. R. Johnson, M. Hofree, J. J. Yan, V. Olivas, B. W. Newton, J. V. Dollen, C. H. Earnshaw, J. Flanagan, E. Chan, S. Asthana, , T. G. Bivona
The paper identifies PDHK1 as a synthetic-essential gene in PTEN-deficient cells and cancers, showing its upregulation drives aerobic glycolysis and correlates with poor patient survival.
bioRxiv · Oct 11, 2018Cancer Biology