E. Chan

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

This study shows that β2 integrins regulate macrophage phagocytosis based on cargo rigidity, acting as a mechanical checkpoint to control engulfment strategies.

Tension-induced adhesion mode switching: the interplay between focal adhesions and clathrin-containing adhesion complexes

This study investigates the spatiotemporal regulation of focal adhesions and clathrin-containing adhesion complexes in breast cancer cells, revealing their inverse relationship with membrane tension and distinct roles in cancer progression.

Tumorigenesis driven by the BRAF V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion

This study shows that BRAFV600E mutations inhibit cell migration and invasion through feedback inhibition of RAC1, requiring secondary mutations to overcome this block and enable tumorigenesis.

Unbiased phosphoproteomics analysis unveils modulation of insulin signaling by extramitotic CDK1 kinase activity in human myotubes

The paper uses phosphoproteomics to show that CDK1 activity modulates insulin signaling and glucose uptake in human myotubes, with group-specific phosphorylation changes observed.

Autophagy mediates cancer cell resistance to doxorubicin induced by the Programmed Death 1/Programmed Death Ligand 1 immune checkpoint axis

This study shows that PD-1/PD-L1 signaling induces autophagy in cancer cells, contributing to drug resistance, and suggests combining PD-1/PD-L1 blockers with autophagy inhibitors could improve chemotherapy effectiveness.

Apoptotic contraction drives target cell release by cytotoxic T cells

This study identifies apoptotic contraction as a mechanism driving CTL dissociation and target cell release.

Treatment of prostate cancer with CD46 targeted 225Ac alpha particle radioimmunotherapy

This study develops and evaluates [225Ac]DOTA-YS5, a radioimmunotherapy for prostate cancer, showing high efficacy in xenograft models but nephrotoxicity at higher doses.

Heparins enhance C1 esterase inhibitor activity: a promising remedy for acute hereditary angioedema

This study shows low-molecular weight heparins enhance C1-INH activity in HAE patients and in vitro, suggesting they could be a cost-effective treatment for acute HAE.

A potent SARS-CoV-2 neutralizing antibody recognizing a conserved epitope with broad mutant variant and SARS-CoV activity.

This paper identifies a SARS-CoV-2 neutralizing antibody, ABP-310, that is effective against multiple variants including Omicron and SARS-CoV, suggesting broad therapeutic potential.

Ex vivo and in vivo evidence that cigarette smoke-exposed T regulatory cells impair host immunity against Mycobacterium tuberculosis

This study shows that cigarette smoke-exposed T regulatory cells impair macrophage control of Mycobacterium tuberculosis infection in vitro and in vivo.

A Marmoset Model for Mycobacterium avium Complex Pulmonary Disease

This study infects marmosets with M. intracellulare to model M. avium complex pulmonary disease, showing infection, immune response, and radiographic changes similar to human disease.

Protective role of the Atg8 1 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease

This study identifies Gabarapl1 as a regulator of glycophagy in diabetic cardiomyopathy, showing its role in preventing glycogen accumulation and diastolic dysfunction.

Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B are Increased in Patients with Kidney Allograft Antibody-Mediated Rejection

The paper identifies increased levels of specific non-HLA autoantibodies in kidney transplant patients with antibody-mediated rejection.

An ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time

The paper examines phenotypic variability in Arabidopsis seed germination time, identifies two loci involved, and models a GA/ABA bistable switch that amplifies variability and contributes to bet hedging.

Genomic and protein structure modelling analysis depicts the origin and infectivity of 2019-nCoV, a new coronavirus which caused a pneumonia outbreak in Wuhan, China

The paper analyzes the genomic and protein structure of 2019-nCoV to determine its origin and infectivity, finding it is a bat coronavirus with weak human ACE2 receptor binding.

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers

The paper identifies WRN helicase as a synthetic lethal target in microsatellite unstable cancers through CRISPR/Cas9 and RNAi screens, showing its essentiality in MSI cell lines.

Covalent Aurora A regulation by the metabolic integrator coenzyme A

This study identifies a novel covalent inhibition mechanism of Aurora A kinase by coenzyme A, showing its regulation under oxidative stress and impact on meiotic spindle formation.

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

The paper identifies PDHK1 as a synthetic-essential gene in PTEN-deficient cells and cancers, showing its upregulation drives aerobic glycolysis and correlates with poor patient survival.

Ecological analyses of mycobacteria in showerhead biofilms and their relevance to human health

This study analyzes mycobacteria in showerhead biofilms across the U.S. and Europe, finding that water source and chemistry influence mycobacterial diversity and abundance, with implications for NTM lung disease transmission.