A Hepatitis C virus genotype 1b post transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo
C. Heuss, P. Rothhaar, R. Burm, J.-Y. Lee, U. Haselmann, L. J. Ströh, P. Ralfs, O. Colasanti, C. S. Tran, N. Schäfer, P. Schnitzler, U. Merle, R. Bartenschlager, A. H. Patel, F. Graw, , V. Lohmann
This paper develops an efficient HCV genotype 1b infectious cell culture model through adaptation, enabling vaccine development and understanding viral evolution post-transplant.
bioRxiv · Mar 28, 2022Microbiology