Author

O. Colasanti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

R. Bartenschlager· 4 shared V. Lohmann· 4 shared C. S. Tran· 3 shared P. Meuleman· 3 shared T.-F. Li· 3 shared H.-E. Huang· 2 shared J. Traut· 2 shared J.-Y. Lee· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

R. Bartenschlager

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4 papers

Recent·Most cited

RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response

T.-F. Li, P. Rothhaar, A. Lang, O. Gruenvogel, O. Colasanti, S. M. Olivera Ugarte, J. Traut, A. Piras, N. Acosta-Rivero, V. Goncalves Magalhaes, E. Springer, A. Betz, H.-E. Huang, J. Park, R. Qiu, , V. Lohmann

This study identifies RBM39 as a regulator of innate immunity by controlling transcription and splicing of key interferon response factors, revealing its potential as a therapeutic target.

bioRxiv · Oct 13, 2023 · PreprintImmunology

Phosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells

C. S. Tran, J. Kersten, M. Breinig, J. Yan, T. Poth, O. Colasanti, T. Riedl, S. Faure-Dupuy, S. Diehl, L. Verhoye, T.-F. Li, M. Lingemann, P. Schult, G. Ahlen, L. Frelin, , V. Lohmann

This study identifies PI4KIII's role in promoting liver cancer invasiveness through cytoskeletal reorganization via PIK3C2γ and Akt2/paxillin-cofilin signaling.

bioRxiv · May 22, 2023Cell Biology

Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation

O. Colasanti, R. Burm, H.-E. Huang, T. Riedl, J. Traut, N. Gillich, T.-F. Li, L. Corneillie, S. Faure-Dupuy, O. Gruenvogel, D. Heide, J.-Y. Lee, C. S. Tran, U. Merle, M. Chironna, , V. Lohmann

This study compares HAV and HCV infections in vivo and in vitro, revealing that HAV induces an innate immune response via MDA5/LGP2 with limited protease-mediated suppression, while HCV activates TLR3 without TRIF cleavage.

bioRxiv · Nov 7, 2022 · PreprintImmunology

A Hepatitis C virus genotype 1b post transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo

C. Heuss, P. Rothhaar, R. Burm, J.-Y. Lee, U. Haselmann, L. J. Ströh, P. Ralfs, O. Colasanti, C. S. Tran, N. Schäfer, P. Schnitzler, U. Merle, R. Bartenschlager, A. H. Patel, F. Graw, , V. Lohmann

This paper develops an efficient HCV genotype 1b infectious cell culture model through adaptation, enabling vaccine development and understanding viral evolution post-transplant.

bioRxiv · Mar 28, 2022Microbiology