Author

F. Graw

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

L. Zimmermann· 2 shared A. H. Patel· 1 shared A. Imle· 1 shared A. Ongoiba· 1 shared A. Oxenius· 1 shared B. Kuropka· 1 shared B. Traore· 1 shared C. Freund· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersImmunology

L. Zimmermann

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses

S. Sid Ahmed, L. Zimmermann, A. Imle, K. Wuebben, N. Tibroni, L. Rauch-Wirth, J. Muench, P. Chlanda, F. Graw, O. T. Fackler

The paper identifies a tissue-intrinsic mechanism where the extracellular matrix restricts HIV-1 infectivity and enhances innate immune detection through conformational changes in viral Env and TLR recognition.

bioRxiv · Nov 22, 2023Immunology

Population context drives cell-to-cell variability in interferon response in epithelial cells

C. Metz-Zumaran, P. Doldan, F. Muraca, Y. Keser, P. Lukas, B. Kuropka, L. Küchenhoff, S. Rastgou Talemi, T. Hoefer, C. Freund, E. A. Cavalcanti-Adam, F. Graw, M. L. Stanifer, S. Boulant

The paper shows that population context affects cell-to-cell variability in interferon response in human intestinal epithelial cells, with edge cells being more responsive than central ones.

bioRxiv · May 22, 2023 · PreprintImmunology

A Hepatitis C virus genotype 1b post transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo

C. Heuss, P. Rothhaar, R. Burm, J.-Y. Lee, U. Haselmann, L. J. Ströh, P. Ralfs, O. Colasanti, C. S. Tran, N. Schäfer, P. Schnitzler, U. Merle, R. Bartenschlager, A. H. Patel, F. Graw, , V. Lohmann

This paper develops an efficient HCV genotype 1b infectious cell culture model through adaptation, enabling vaccine development and understanding viral evolution post-transplant.

bioRxiv · Mar 28, 2022Microbiology

Number and proportion of P. falciparum gametocytes vary from acute infection to chronic parasite carriage despite unaltered sexual commitment rate

H. van Dijk, M. Kampmann, N. Ferreira Lima, M. Gabel, U. Dabbas, S. Doumbo, H. Cisse, S. Li, M. Jeninga, R. Thomson Luque, D. Doumtabe, M. Petter, K. Kayentao, A. Ongoiba, T. Bousema, , S. Portugal

The paper compares gametocyte levels and sexual commitment in P. falciparum infections during dry and wet seasons, finding increased mature gametocytes in asymptomatic dry season carriers without changes in sexual commitment.

bioRxiv · Nov 5, 2021 · PreprintMicrobiology

HCV spread kinetics reveal varying contributions of transmission modes to infection dynamics

K. Durso-Cain, P. Kumberger, Y. Schälte, T. Fink, H. Dahari, J. Hasenauer, S. L. Uprichard, F. Graw

This study quantifies the contributions of cell-free and cell-to-cell transmission modes to HCV spread using in vitro experiments and a spatially-explicit mathematical model.

bioRxiv · Apr 12, 2021Microbiology

Locally confined IFNγ production by CD4+ T cells provides niches for murine cytomegalovirus replication in the salivary gland

J. Oderbolz, N. Zangger, L. Zimmermann, I. Sandu, J. Starruss, F. Graw, A. Oxenius

This study shows that CD4+ T cells produce IFNγ locally in clusters near MCMV infection foci in salivary glands, enabling regional protection while allowing continued viral replication.

bioRxiv · Jan 14, 2021 · PreprintImmunology