Author

P. Ralfs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3

Frequent Co-Authors

A. Grakoui· 2 shared A. Vanderheiden· 2 shared L. J. Anderson· 2 shared M. S. Suthar· 2 shared T. Chirkova· 2 shared A. A. Upadhyay· 1 shared A. C. Lowen· 1 shared A. H. Patel· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

A. Grakoui

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Hepatitis C virus genotype 1b post transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo

C. Heuss, P. Rothhaar, R. Burm, J.-Y. Lee, U. Haselmann, L. J. Ströh, P. Ralfs, O. Colasanti, C. S. Tran, N. Schäfer, P. Schnitzler, U. Merle, R. Bartenschlager, A. H. Patel, F. Graw, , V. Lohmann

This paper develops an efficient HCV genotype 1b infectious cell culture model through adaptation, enabling vaccine development and understanding viral evolution post-transplant.

bioRxiv · Mar 28, 2022Microbiology

Plasmacytoid dendritic cells produce type I interferon and reduce viral replication in airway epithelial cells after SARS-CoV-2 infection

L. Cervantes-Barragan, A. Vanderheiden, C. J. Royer, M. E. Davis-Gardner, P. Ralfs, T. Chirkova, L. J. Anderson, A. Grakoui, M. S. Suthar

This study shows that plasmacytoid dendritic cells recognize SARS-CoV-2, produce type I and III interferons, and reduce viral replication in infected airway epithelial cells.

bioRxiv · May 12, 2021 · PreprintImmunology

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

A. Vanderheiden, P. Ralfs, T. Chirkova, A. A. Upadhyay, M. G. Zimmerman, S. Bedoya, H. Aoued, G. K. Tharp, K. Pellegrini, A. C. Lowen, V. D. Menachery, L. J. Anderson, A. Grakoui, S. E. Bosinger, M. S. Suthar

This study shows SARS-CoV-2 infects human airway epithelial cultures, induces pro-inflammatory cytokines, and is inhibited by type I and III IFNs.

bioRxiv · May 19, 2020Microbiology