Author

U. Merle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:flow cytometry· 1

Frequent Co-Authors

R. Bartenschlager· 4 shared J.-Y. Lee· 3 shared C. J. Neufeldt· 2 shared C. S. Tran· 2 shared M. Binder· 2 shared M. Cortese· 2 shared O. Colasanti· 2 shared P. Meuleman· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersMicrobiology

R. Bartenschlager

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Distinct Functional States of Neutrophils by Actin Disassembly and NF-kB/STAT3 Signaling

G. H. Wabnitz, N. Heineken, J.-C. Schumacher, T. Exner, F. Neuenfeldt, J. Habicht, F. Kahlich, H. Platzer, U. Merle, T. Renkawitz, Y. Samstag, R. Grieshaber-Bouyer, S. Autenrieth

This study identifies two distinct neutrophil states in mice and patients, driven by actin dynamics and NF-kB/STAT3 signaling, with different functional outcomes.

bioRxiv · Jul 14, 2023 · PreprintImmunology

Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation

O. Colasanti, R. Burm, H.-E. Huang, T. Riedl, J. Traut, N. Gillich, T.-F. Li, L. Corneillie, S. Faure-Dupuy, O. Gruenvogel, D. Heide, J.-Y. Lee, C. S. Tran, U. Merle, M. Chironna, , V. Lohmann

This study compares HAV and HCV infections in vivo and in vitro, revealing that HAV induces an innate immune response via MDA5/LGP2 with limited protease-mediated suppression, while HCV activates TLR3 without TRIF cleavage.

bioRxiv · Nov 7, 2022 · PreprintImmunology

A Hepatitis C virus genotype 1b post transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo

C. Heuss, P. Rothhaar, R. Burm, J.-Y. Lee, U. Haselmann, L. J. Ströh, P. Ralfs, O. Colasanti, C. S. Tran, N. Schäfer, P. Schnitzler, U. Merle, R. Bartenschlager, A. H. Patel, F. Graw, , V. Lohmann

This paper develops an efficient HCV genotype 1b infectious cell culture model through adaptation, enabling vaccine development and understanding viral evolution post-transplant.

bioRxiv · Mar 28, 2022Microbiology

Microscopy-based assay for semi-quantitative detection of SARS-CoV-2 specific antibodies in human sera

C. Pape, R. Remme, A. Wolny, S. Olberg, S. Wolf, L. Cerrone, M. Cortese, S. Klaus, B. Lucic, S. Ullrich, M. Anders-Össwein, S. Wolf, C. Berati, C. J. Neufeldt, M. Ganter, , V. Laketa

The paper develops a semi-quantitative microscopy-based assay to detect SARS-CoV-2 specific antibodies in human sera, providing a sensitive and specific method for serological analysis.

BioEssays · Dec 30, 2020Peer-reviewedMicrobiology

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

C. J. Neufeldt, B. Cerikan, M. Cortese, J. Frankish, J.-Y. Lee, A. Plociennikowska, F. Heigwer, S. Joecks, S. S. Burkart, D. Y. Zander, M. Gendarme, B. El Debs, N. Halama, U. Merle, M. Boutros, , R. Bartenschlager

This study shows SARS-CoV-2 triggers a pro-inflammatory cytokine response via cGAS-STING and NF-κB in epithelial cells, which may contribute to severe disease.

bioRxiv · Jul 21, 2020Microbiology