Author

C. Higgins

Queen's University Belfast

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. de Weck· 1 shared A. Schulz· 1 shared Caitriona HolohaniD· 1 shared D. Badescu· 1 shared D. Hu· 1 shared DB Longley· 1 shared E. K. Parkinson· 1 shared Emma EvergreniD· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. de Weck

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Author profile →

5 papers

Recent·Most cited

Genome evolution and introgression in the New Zealand mud snails Potamopyrgus estuarinus and Potamopyrgus kaitunuparaoa

P. Fields, J. Jalinsky, L. Bankers, K. McElroy, J. Sharbrough, C. Higgins, M. Morgan-Richards, J. Boore, M. Neiman, J. M. Logsdon

This paper sequences and analyzes the genomes of two New Zealand snail species, showing their genetic similarity, introgression between them, and their relationship to the invasive P. antipodarum.

bioRxiv · Oct 31, 2023Evolutionary Biology

Second Harmonic Generation Imaging Reveals Entanglement of Collagen Fibers in the Elephant Trunk Skin Dermis

A. Schulz, M. Plotczyk, S. Sordilla, M. Boyle, K. Singal, J. Reidenberg, D. Hu, C. Higgins

The paper uses second harmonic generation microscopy to analyze collagen fiber organization in elephant trunk skin, revealing a bimodal distribution and entanglement that enables both flexibility and strength.

bioRxiv · Aug 11, 2023Bioengineering

Hydraulic Conductivity of The Hemp Stems Under Water Stress

M. Yuksel, H. A. Al-agele, L. Nackley, C. Higgins

This study investigates the hydraulic conductivity of hemp stems under water stress, finding that xylem area significantly affects vulnerability curves and that hemp is more sensitive to water stress than other plants.

bioRxiv · Jun 9, 2023 · PreprintCell Biology

Regulation of FLIP(L) and TRAIL-R2 signalling by the SCFSkp2 Ubiquitin Ligase Complex

J.A. Roberts, Caitriona Holohan, Tamas Sessler, J E Fox, C. Higgins, Greti E. Fiedler, Joanna Majkut, Nyree Crawford, JS Riley, H Khawaja, Luke M. Humphreys, J Ferris, Emma Evergren, Paul N. Moynagh, SS McDade, DB Longley

The paper shows SCFSkp2 ubiquitin ligase complex regulates FLIP(L) stability through direct interaction with Cullin-1, affecting TRAIL-R2 signaling and caspase-8 processing.

bioRxiv · Aug 2, 2019 · PreprintMolecular Biology

Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific genetic changes associated with immortalisation and malignancy.

R. Veeramachaneni, T. Walker, A. de Weck, T. Revil, D. Badescu, J. O'Sullivan, C. Higgins, L. Elliott, T. Liloglou, J. M. Risk, R. Shaw, L. Hampson, I. Hampson, S. Dearden, R. Woodwards, , N. Thakker

This study identifies stage-specific genetic changes in head and neck squamous cell carcinoma progression, highlighting CSMD1 inactivation as a key factor in early carcinogenesis and metastasis.

bioRxiv · Jul 9, 2018Cancer Biology