Molecular BiologybioRxivPreprint
Regulation of FLIP(L) and TRAIL-R2 signalling by the SCFSkp2 Ubiquitin Ligase Complex
J.A. Roberts, Caitriona Holohan, Tamas Sessler…·DB Longley
The paper shows SCFSkp2 ubiquitin ligase complex regulates FLIP(L) stability through direct interaction with Cullin-1, affecting TRAIL-R2 signaling and caspase-8 processing.
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