R. Shaw

Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFos

This study identifies Arid1a loss as a driver of aggressive prostate cancer in mice, accelerating tumorigenesis and promoting a proliferative, collagen-poor phenotype through cooperation with cFos.

The Legionella collagen-like protein employs a unique binding mechanism for the recognition of host glycosaminoglycans

This study determines the crystal structure of Legionella collagen-like protein and reveals its unique binding mechanism for sulphated glycosaminoglycans.

Nucleo-cytoplasmic environment modulates spatio-temporal p53 phase separation

This study shows that p53 phase separation and condensate formation are modulated by the nucleo-cytoplasmic environment and cancer-associated mutations affect condensate stability and DNA binding.

γδ T cells impair airway macrophage differentiation in lung adenocarcinoma

The paper identifies that CD27+ γδ T cells impair the differentiation of tumor-associated macrophages into airway macrophages in lung adenocarcinoma.

ERBB signalling contributes to immune evasion in KRAS-driven lung adenocarcinoma

The paper investigates how ERBB signaling contributes to immune evasion in KRAS-driven lung adenocarcinoma using a novel mouse model and finds that transient ERBB blockade can restore immune surveillance when combined with PD1 blockade.

DDX5 (p68) orchestrates β-catenin, RelA and SP1 mediated MGMT gene expression: Implication in TMZ chemoresistance

This study identifies DDX5 (p68) as a master regulator of MGMT gene expression through interactions with β-catenin, RelA, and SP1, contributing to TMZ chemoresistance in colon cancer.

Hypo-responsiveness of human alveolar macrophages to IFN-γ is not due to attenuated STAT1 signaling

This study shows human alveolar macrophages have a limited proteomic response to IFN-γ compared to monocytes, despite normal STAT1 signaling.

PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer.

This study identifies ARF6 as a critical vulnerability in PTEN-deficient ovarian cancer, showing its role in integrin-dependent invasion and its inverse association with patient outcomes.

Spatial regulation of the glycocalyx component Podocalyxin is a switch for pro-metastatic function

This study identifies PODXL as a decoy receptor for GAL3, revealing its role in promoting metastasis through integrin-based invasion and differential cortical targeting regulated by ubiquitination.

Extensive genome introgression between domestic ferret and European polecat during population recovery in Great Britain.

The paper quantifies genome introgression between British European polecats and domestic ferrets, identifying genes under selection related to cognitive function and sight.

Immunogenic SARS-CoV2 Epitopes Defined by Mass Spectrometry

This study identifies novel SARS-CoV-2 epitopes using mass spectrometry and validates their immunogenicity by T cell recognition.

Single-cell analysis uncovers differential regulation of lung γδ T cell subsets by the co-inhibitory molecules, PD-1 and TIM-3

This study identifies differential regulation of lung γδ T cell subsets by PD-1 and TIM-3 using single-cell RNA sequencing and flow cytometry.

Absent expansion of pericentral hepatocytes and altered physiology in Axin2CreERT2 mice

This study re-evaluates lineage tracing in Axin2CreERT2 mice and reports absence of pericentral hepatocyte expansion and altered Wnt pathway physiology.

Structure and functional analysis of the Legionella chitinase ChiA reveals a novel mechanism of metal-dependent mucin degradation

This study characterizes the structure and function of Legionella pneumophila's chitinase ChiA, revealing its role in mucin degradation and bacterial pathogenesis.

Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific genetic changes associated with immortalisation and malignancy.

This study identifies stage-specific genetic changes in head and neck squamous cell carcinoma progression, highlighting CSMD1 inactivation as a key factor in early carcinogenesis and metastasis.

MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size

This study shows that MFF-dependent mitochondrial fission limits axonal mitochondria size, which affects presynaptic release and axon branching by altering Ca2+ uptake capacity.