Discovery of a redox-thiol switch regulating cellular energy metabolism
X.-H. Gao, L. Li, M. Parisien, M. Mcleod, J. Wu, I. Bederman, Z. Gao, D. Krokowski, S. M. Chirieleison, L. Diatchenko, D. Abbott, V. Yee, C. Hoppel, R. Kibbey, T. Holyoak, , M. Hatzoglou
The paper identifies a Redox Thiol Switch (RTSGS) that regulates cellular energy metabolism by switching between S-glutathionylation and S-sulfhydration, with PCK2 as a novel target.
bioRxiv · Jan 14, 2019 · PreprintBiochemistry