Author

I. Bederman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Abbas· 2 shared A. Vaziri-Gohar· 2 shared B. Willard· 2 shared H. Brunengraber· 2 shared H. J. Graor· 2 shared J. J. Hue· 2 shared J. M. Salvino· 2 shared J. M. Winter· 2 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. Abbas

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Increased glucose availability sensitizes pancreatic cancer to chemotherapy

A. Vaziri-Gohar, J. J. Hue, H. J. Graor, A. Abbas, M. Zarei, O. Hajihassani, G. Titomihelakis, J. Feczko, M. Rathore, R. Wang, M. Zarei, M. Goudarzi, R. Zhang, B. Willard, L. Zhang, , J. M. Winter

This study shows that high glucose levels increase the effectiveness of chemotherapy in pancreatic cancer by reducing glutathione biosynthesis, which enhances oxidative stress in cancer cells.

bioRxiv · Apr 29, 2022Cancer Biology

Intracellular Vesicle Entrapment of Nanobubble Ultrasound Contrast Agents Targeted to PSMA Promotes Prolonged Enhancement and Stability In Vivo and In Vitro

R. Perera, E. Abenojar, P. Nittayacharn, X. Wang, G. Ramamurthy, P. Peiris, I. Bederman, J. Basilion, A. Exner

This study investigates how PSMA-targeted nanobubbles enhance ultrasound imaging in prostate tumors by being internalized and retained in intracellular vesicles, leading to prolonged signal and stability.

bioRxiv · May 11, 2021Cancer Biology

Cancer cells are sensitive to wild-type IDH1 inhibition under nutrient limitation

A. Vaziri-Gohar, J. J. Hue, H. J. Graor, E. Prendergast, V. Chen, J. Cassel, F. S. Mohammed, A. Abbas, K. Dukleska, I. Khokhar, O. Hajhassani, M. Zarei, R. Wang, L. D. Rothermel, I. Bederman, , J. M. Winter

This study shows that wild-type IDH1 is a metabolic target in pancreatic cancer cells under nutrient limitation, and FDA-approved drugs can inhibit it effectively in preclinical models.

bioRxiv · Nov 19, 2020 · PreprintCancer Biology

Discovery of a redox-thiol switch regulating cellular energy metabolism

X.-H. Gao, L. Li, M. Parisien, M. Mcleod, J. Wu, I. Bederman, Z. Gao, D. Krokowski, S. M. Chirieleison, L. Diatchenko, D. Abbott, V. Yee, C. Hoppel, R. Kibbey, T. Holyoak, , M. Hatzoglou

The paper identifies a Redox Thiol Switch (RTSGS) that regulates cellular energy metabolism by switching between S-glutathionylation and S-sulfhydration, with PCK2 as a novel target.

bioRxiv · Jan 14, 2019 · PreprintBiochemistry