Author

M. McLeod

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

T. Holyoak· 2 shared A. Broer· 1 shared A. Ganesan· 1 shared A. Yadav· 1 shared B. Willard· 1 shared C. Hoppel· 1 shared D. Abbott· 1 shared D. Krokowski· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

T. Holyoak

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Author profile →

3 papers

Recent·Most cited

Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19)

J. Xu, Z. Hu, L. Dai, A. Yadav, Y. Jiang, A. Broer, M. Gardiner, M. McLeod, R. Yan, S. Broer

This paper identifies high-affinity inhibitors of B0AT1 and elucidates their mechanism of action through cryo-EM structures.

bioRxiv · Feb 18, 2024Biochemistry

The H163A Mutation Unravels an Oxidized Conformation of the SARS-CoV-2 Main Protease and Opens a New Avenue for Anti-Viral Therapeutic Design

N. Tran, S. Dasari, S. Barwell, M. McLeod, S. Kalyaanamoorthy, T. Holyoak, A. Ganesan

This study identifies an oxidized conformation of SARS-CoV-2 Mpro through a point mutation and suggests it could inform new antiviral strategies.

bioRxiv · Dec 16, 2022 · PreprintBiochemistry

Discovery of a redox-thiol switch regulating cellular energy metabolism

X.-H. Gao, L. Li, M. Parisien, M. Mcleod, J. Wu, I. Bederman, Z. Gao, D. Krokowski, S. M. Chirieleison, L. Diatchenko, D. Abbott, V. Yee, C. Hoppel, R. Kibbey, T. Holyoak, , M. Hatzoglou

The paper identifies a Redox Thiol Switch (RTSGS) that regulates cellular energy metabolism by switching between S-glutathionylation and S-sulfhydration, with PCK2 as a novel target.

bioRxiv · Jan 14, 2019 · PreprintBiochemistry