B. Willard

Integrated forward and reverse degradomics uncovers the proteolytic landscape of aortic aneurysms and the roles of MMP9 and mast cell chymase

The paper uses forward and reverse degradomics to analyze proteolytic landscapes in aortic aneurysms, identifying key proteases like MMP9 and CMA1 and their roles in extracellular matrix remodeling.

TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk

This study identifies that TLR9 activation requires phosphorylation of two specific tyrosine residues by EGFR and Syk, which is critical for downstream signaling.

Carbapenem-induced β-lactamase-isoform expression trends in Acinetobacter baumannii

This study shows that carbapenem exposure leads to concentration- and carbapenem-dependent trends in β-lactamase-isoform expression in Acinetobacter baumannii, suggesting non-stochastic resistance mechanisms.

Epithelial cytokeratin 6a restricts secretory autophagy of proinflammatory cytokines by interacting with Sec16A

This study shows that K6a restricts secretory autophagy of proinflammatory cytokines by interacting with Sec16A, reducing cytokine secretion in corneal epithelial cells.

Keratin 6a attenuates Toll-like receptor-triggered proinflammatory response in corneal epithelial cells by suppressing ELKS/IKKϵ-dependent activation of NF-κB

This study shows that keratin 6a suppresses TLR-triggered inflammation in corneal epithelial cells by modulating ELKS/IKKε-dependent NF-κB activation, preventing excessive cytokine and chemokine production.

Increased glucose availability sensitizes pancreatic cancer to chemotherapy

This study shows that high glucose levels increase the effectiveness of chemotherapy in pancreatic cancer by reducing glutathione biosynthesis, which enhances oxidative stress in cancer cells.

Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice

This study shows elevated trimethylamine (TMA) in alcohol-associated hepatitis patients and demonstrates that inhibiting gut microbial TMA production protects mice from ethanol-induced liver injury.

Gut Microbe-Targeted Choline Trimethylamine Lyase Inhibition Improves Obesity Via Rewiring of Host Circadian Rhythms

The paper shows that inhibiting gut microbial choline TMA-lyase reduces obesity in mice by altering microbiome composition and host circadian rhythms.

Dietary restriction transforms the protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner

Dietary restriction alters sulfhydrated protein enrichment and downstream pathways in multiple tissues, partly dependent on cystathionine γ-lyase.

Acute phase protein, α-1-acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses.

This study shows AGP-1 enhances TLR-2 but not TLR-4 mediated inflammatory responses in vitro and in vivo, suggesting a role in sepsis pathobiology.

Chk1 Phosphorylates Cdh1 to Promote SCFβTRCP-Dependent Degradation of Cdh1 During S-Phase

This study shows Chk1 phosphorylates Cdh1 to promote its SCFβTRCP-dependent degradation during S-phase, facilitating efficient S-phase entry and cellular proliferation.

Discovery of a redox-thiol switch regulating cellular energy metabolism

The paper identifies a Redox Thiol Switch (RTSGS) that regulates cellular energy metabolism by switching between S-glutathionylation and S-sulfhydration, with PCK2 as a novel target.